The present invention relates to a process for the hydroxylation of an aromatic compound comprising at least one alkoxy group, comprising a step (a) of reacting said aromatic compound comprising at least one alkoxy group with hydrogen peroxide in the presence of a catalyst, in a solvent comprising water, an alcohol, or a mixture of alcohols.

The present invention relates to a process for the hydroxylation of an aromatic compound comprising at least one alkoxy group, comprising a step (a) of reacting said aromatic compound comprising at least one alkoxy group with hydrogen peroxide in the presence of a catalyst, in a solvent comprising water, an alcohol, or a mixture of alcohols.

The invention provides processes for the preparation of HU-910, which are scalable to industrial purposes, using safer reagents and having high yield and pure product and a crystalline structure of HU-910, which is a unique product thereof.

The invention provides processes for the preparation of HU-910, which are scalable to industrial purposes, using safer reagents and having high yield and pure product and a crystalline structure of HU-910, which is a unique product thereof.

It is an object of the present disclosure to provide a method for producing a reduced coenzyme Q10 Form II crystal or a crystalline solid thereof, which is capable of stably producing a reduced coenzyme Q10 Form II crystal or a crystalline solid thereof.

The present embodiment is a method for producing a reduced coenzyme Q10 Form II crystal or a crystalline solid thereof, the method using a crystallizer provided with a crystallization unit, a turbidity detection unit capable of detecting a turbidity in the crystallization unit, and a temperature adjustment unit capable of adjusting a temperature in the crystallization unit, and the method including: accommodating a mixed solution containing an alcohol and a reduced coenzyme Q10 in the crystallization unit; adding a reduced coenzyme Q10 Form II crystal as a seed crystal to the mixed solution; and precipitating a reduced coenzyme Q10 Form II crystal in the mixed solution after adding the seed crystal, wherein the precipitation includes controlling a temperature with the temperature adjustment unit based on a turbidity change rate obtained by the turbidity detection unit.

It is an object of the present disclosure to provide a method for producing a reduced coenzyme Q10 Form II crystal or a crystalline solid thereof, which is capable of stably producing a reduced coenzyme Q10 Form II crystal or a crystalline solid thereof.

The present embodiment is a method for producing a reduced coenzyme Q10 Form II crystal or a crystalline solid thereof, the method using a crystallizer provided with a crystallization unit, a turbidity detection unit capable of detecting a turbidity in the crystallization unit, and a temperature adjustment unit capable of adjusting a temperature in the crystallization unit, and the method including: accommodating a mixed solution containing an alcohol and a reduced coenzyme Q10 in the crystallization unit; adding a reduced coenzyme Q10 Form II crystal as a seed crystal to the mixed solution; and precipitating a reduced coenzyme Q10 Form II crystal in the mixed solution after adding the seed crystal, wherein the precipitation includes controlling a temperature with the temperature adjustment unit based on a turbidity change rate obtained by the turbidity detection unit.

It is an object of the present disclosure to provide a method for producing a reduced coenzyme Q10 Form II crystal or a crystalline solid thereof, which is excellent in the filterability of a slurry containing a reduced coenzyme Q10 Form II crystal.

The present embodiment is a method for producing a reduced coenzyme Q10 Form II crystal or a crystalline solid thereof, including: adding a reduced coenzyme Q10 Form II crystal as a seed crystal to a mixed solution containing an alcohol and a reduced coenzyme Q10; and precipitating a reduced coenzyme Q10 Form II crystal in the mixed solution after adding the seed crystal, wherein a change rate of formazin turbidity (FTU) is maintained at 15 FTU/min or more for 80% or more of a period during which the formazin turbidity (FTU) shifts from 1,000 to 10,000 in the precipitation.

A method of obtaining a volatile or semi-volatile natural antioxidant by toasting a comestible byproduct, natural antioxidants obtained by toasting the comestible byproduct, and packaging films incorporating such natural antioxidants are described herein.

A method of obtaining a volatile or semi-volatile natural antioxidant by toasting a comestible byproduct, natural antioxidants obtained by toasting the comestible byproduct, and packaging films incorporating such natural antioxidants are described herein.

A method of obtaining a volatile or semi-volatile natural antioxidant by toasting a comestible byproduct, natural antioxidants obtained by toasting the comestible byproduct, and packaging films incorporating such natural antioxidants are described herein.