Provided are synthesis processes and intermediates for preparing cannabinoids and analogs.

Provided are synthesis processes and intermediates for preparing cannabinoids and analogs.

This invention relates to methods for the synthesis of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione which are useful as intermediates in the manufacture of pharmaceutically active ingredients.

This invention relates to methods for the synthesis of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione which are useful as intermediates in the manufacture of pharmaceutically active ingredients.

Provided are methods for the meta-selective CH arylations of arene alcohol-based substrates. The methods combine the transient norbornene strategy with a quinoline-based acetal scaffold to achieve the formation of biaryl compounds. These processes establish a foundation for catalytic polyfunctionalization of alcohol-based compounds. The method comprises attaching a heterocyclic hemiacetal scaffold to an aromatic alcohol or a substituted aromatic alcohol; reacting the aromatic or substituted aromatic alcohol having the heterocyclic hemiacetal scaffold attached with an alkyl or aryl iodide in a reaction mix comprising a palladium catalyst, a silver salt, and carboxymethyl norbornene to generate a meta-arylated arene conjugated to the heterocyclic hemiacetal scaffold; and then cleaving the heterocyclic hemiacetal scaffold from the meta-arylated arene alcohol.

Disclosed herein are a phenanthrene-based compound with a high-refractive index and a preparation method therefor. The compound has a phenanthrene-based complex cardo structure and can be used as a monomer in optical resins requiring a refractive index of 1.7 or higher. Due to the phenanthrene-based complex cardo structure of the compound, the fluidity of the molecular chains can be maximally suppressed, allowing for the production of resins with excellent thermal stability, characterized by a high glass transition temperature.

The present invention relates to a process for preparing methyl methacrylate by direct oxidative esterification of methacrolein. Methyl methacrylate is used in large amounts for preparing polymers and copolymers with other polymerizable compounds. In addition, methyl methacrylate is an important synthesis unit for a variety of specialty esters based on methacrylic acid (MAA) which can be prepared by transesterification with the appropriate alcohol. There is consequently a great interest in very simple, economic and environmentally friendly processes for preparing this starting material.

In particular the present invention relates to an optimized workup of the reactor effluent from the oxidative esterification of methacrolein by means of which process waste streams can be minimized and process water can be recycled in optimal fashion. The methacrylic acid generated in the process is also optimally recovered and isolated or converted into the commodity alkyl methacrylate. This process moreover has the advantage that fewer demands than described in the prior art are placed on plant apparatus configuration.

Disclosed are methods for preparing zingerone from ginger using alkaline solutions, as well as compositions obtained using these methods, and methods for using these compositions. Specifically disclosed are pharmaceutical compositions, and treatment methods employing zingerone in combination with other therapeutics such as gentamicin, vancomycin, and cefotaxime.

Disclosed are methods for preparing zingerone from ginger using alkaline solutions, as well as compositions obtained using these methods, and methods for using these compositions. Specifically disclosed are pharmaceutical compositions, and treatment methods employing zingerone in combination with other therapeutics such as gentamicin, vancomycin, and cefotaxime.

The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: ##STR00001## or a co-crystal, solvate, salt or combination thereof.