Processes for preparing 3-substituted phenylalkylamines comprising reacting a phenyl boronic compound with an ?-? unsaturated carbonyl-containing compound via an asymmetric 1,4-addition reaction, followed by reductive alkylation. The processes may be useful in the synthesis of tapentadol.

The present invention relates to compounds of formula (I):

##STR00001##

in which R1 is a hydrogen atom, a phenyl radical, or a straight or branched, saturated or unsaturated hydrocarbon radical having 1 to 8 carbon atoms.

The present invention relates to compounds of formula (I):

##STR00001##

in which R1 is a hydrogen atom, a phenyl radical, or a straight or branched, saturated or unsaturated hydrocarbon radical having 1 to 8 carbon atoms.

The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (NDGA) compounds and butane bridge modified tetra-O-substituted NDGA compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, metabolic diseases, such as diabetes and hypertension, or a proliferative disease, such as diverse types of cancers.

Processes for preparing 3-substituted phenylalkylamines comprising reacting a phenyl boronic compound with an - unsaturated carbonyl-containing compound via an asymmetric 1,4-addition reaction, followed by reductive alkylation. The processes may be useful in the synthesis of tapentadol.

Processes for preparing 3-substituted phenylalkylamines comprising reacting a phenyl boronic compound with an - unsaturated carbonyl-containing compound via an asymmetric 1,4-addition reaction, followed by reductive alkylation. The processes may be useful in the synthesis of tapentadol.

The disclosure provides a dual-catalysis system for direct conversion of olefins to alcohols. The cooperative catalytic system contains one oxidizing catalyst and one transfer-hydrogenation catalyst. A wide variety of olefins, including aromatic and aliphatic olefins, can be used as the reactant. The transformation proceeds with anti-Markovnikov selectivity, and in some aspects provides primary alcohols as major products. The disclosure further provides a system for oxidation of olefins with anti-Markovnikov selectivity.

The disclosure provides a dual-catalysis system for direct conversion of olefins to alcohols. The cooperative catalytic system contains one oxidizing catalyst and one transfer-hydrogenation catalyst. A wide variety of olefins, including aromatic and aliphatic olefins, can be used as the reactant. The transformation proceeds with anti-Markovnikov selectivity, and in some aspects provides primary alcohols as major products. The disclosure further provides a system for oxidation of olefins with anti-Markovnikov selectivity.

The present invention relates to a process for thermolytic fragmentation of a sugar into a composition comprising C.sub.1-C.sub.3 oxygenates. In particular, it relates to the use of heat carrying particles providing improved yields of C.sub.1-C.sub.3 oxygenates and improved fluidization characteristics making it suitable for industrial scale production of e.g. glycolaldehyde. It also regards a circulating fluidized bed system comprising the heat carrying particles.

The present invention relates to a process for thermolytic fragmentation of a sugar into a composition comprising C.sub.1-C.sub.3 oxygenates. In particular, it relates to the use of heat carrying particles providing improved yields of C.sub.1-C.sub.3 oxygenates and improved fluidization characteristics making it suitable for industrial scale production of e.g. glycolaldehyde. It also regards a circulating fluidized bed system comprising the heat carrying particles.