Patent classifications
C07C47/565
COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
- Prabha N. Ibrahim ,
- Dean R. Artis ,
- Ryan Bremer ,
- Gaston Habets ,
- Shumeye Mamo ,
- Marika Nespi ,
- Chao Zhang ,
- Jiazhong Zhang ,
- Yong-Liang Zhu ,
- Rebecca Zuckerman ,
- Brian West ,
- Yoshisa Suzuki ,
- James Tsai ,
- Klaus-Peter Hirth ,
- Gideon Bollag ,
- Wayne Spevak ,
- Hanna Cho ,
- Samuel J. Gillette ,
- Guoxian Wu ,
- Hongyao Zhu ,
- Shenghua Shi
Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
PROCESS FOR PREPARING 3-CHLORO-2-VINYLPHENYLSULFONATES
The present invention relates to a new process for preparing 3-chloro-2-vinylphenylsulfonate derivatives.
PROCESS FOR PREPARING 3-CHLORO-2-VINYLPHENYLSULFONATES
The present invention relates to a new process for preparing 3-chloro-2-vinylphenylsulfonate derivatives.
3,6-dichlorosalicylic acid compounds and related synthetic processes
The present disclosure relates, in general, to 5-halo-3,6-dichlorosalicylic acid compounds, 5-halo-3,6-dichlorosalicyaldehyde compounds, processes for preparing 5-halo-3,6-dichlorosalicylic acid compounds, processes for preparing 5-halo-3,6-dichlorosalicyaldehyde compounds, processes for preparing 3,6-dichlorosalicylic acid compounds, and processes that employ such compounds as intermediates in the preparation of the herbicide dicamba.
3,6-DICHLOROSALICYLIC ACID COMPOUNDS AND RELATED SYNTHETIC PROCESSES
The present disclosure relates, in general, to 5-halo-3,6-dichlorosalicylic acid compounds, 5-halo-3,6-dichlorosalicy-aldehyde compounds, processes for preparing 5-halo-3,6-dichlorosalicylic acid compounds, processes for preparing 5-halo-3,6-di-chlorosalicyaldehyde compounds, processes for preparing 3,6-dichlorosalicylic acid compounds, and processes that employ such compounds as intermediates in the preparation of the herbicide dicamba.
SYNTHESIS OF INTERMEDIATES FOR PRODUCING PROSTACYCLIN DERIVATIVES
The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.
SYNTHESIS OF INTERMEDIATES FOR PRODUCING PROSTACYCLIN DERIVATIVES
The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.
IRE-1alpha INHIBITORS
Compounds which directly inhibit IRE-1 activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.
Small molecule xanthine oxidase inhibitors and methods of use
Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
Small molecule xanthine oxidase inhibitors and methods of use
Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.