C07C49/697

PROCESS FOR PREPARING TAPINAROF

The present invention provides processes for the preparation of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and novel intermediates used therein. In some embodiments the 3, 5-Dihydroxy-4-isopropyl-trans-stilbene is prepared from (E)-2-chloro-2-isopropyl-5-styrylcyclohexane-1,3-dione. Also disclosed are crystal forms of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and pharmaceutical compositions comprising same.

Method for Fluoroalkylation of Enamines

The invention discloses a method for fluoroalkylation of enamines with a fluoro alkyl halide in the presence of a base.

Method for Fluoroalkylation of Enamines

The invention discloses a method for fluoroalkylation of enamines with a fluoro alkyl halide in the presence of a base.

INHIBITORS OF THE N-TERMINAL DOMAIN OF THE ANDROGEN RECEPTOR

The present disclosure provides compounds and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.

INHIBITORS OF THE N-TERMINAL DOMAIN OF THE ANDROGEN RECEPTOR

The present disclosure provides compounds and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.

Anticonvulsant compounds
11345652 · 2022-05-31 · ·

The present application relates to compounds and methods for reducing the severity of convulsant activity or epileptic seizures, or for the treatment of chronic or acute pain.

Anticonvulsant compounds
11345652 · 2022-05-31 · ·

The present application relates to compounds and methods for reducing the severity of convulsant activity or epileptic seizures, or for the treatment of chronic or acute pain.

Method for fluoroalkylation of enamines

The invention discloses a method for fluoroalkylation of enamines with a fluoro alkyl halide in the presence of a base.

Method for fluoroalkylation of enamines

The invention discloses a method for fluoroalkylation of enamines with a fluoro alkyl halide in the presence of a base.

Small molecule stimulators of steroid receptor coactivator proteins and their use in the treatment of cancer

Small molecule stimulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing cancer. Also provided are methods for stimulating SRC family proteins in a cell.