There is provided a method for producing a C2-C20 fluorine-containing organic acid with reduced fluorine-free organic compound. A method for producing a C2-C20 fluorine-containing organic acid, wherein the method comprises contacting a mixture containing a C2-C20 fluorine-containing organic acid and a fluorine-free organic compound with a concentrated sulfuric acid and then separating a C2-C20 fluorine-containing organic acid phase from a concentrated sulfuric acid phase, wherein the contacting is conducted such that an amount of water present in the concentrated sulfuric acid phase is 10% by mass or less, and the C2-C20 fluorine-containing organic acid is obtained in the form of the C2-C20 fluorinated organic acid phase having a reduced content ratio of the fluorine-free organic compound compared with said mixture.

There is provided a method for producing a C2-C20 fluorine-containing organic acid with reduced fluorine-free organic compound. A method for producing a C2-C20 fluorine-containing organic acid, wherein the method comprises contacting a mixture containing a C2-C20 fluorine-containing organic acid and a fluorine-free organic compound with a concentrated sulfuric acid and then separating a C2-C20 fluorine-containing organic acid phase from a concentrated sulfuric acid phase, wherein the contacting is conducted such that an amount of water present in the concentrated sulfuric acid phase is 10% by mass or less, and the C2-C20 fluorine-containing organic acid is obtained in the form of the C2-C20 fluorinated organic acid phase having a reduced content ratio of the fluorine-free organic compound compared with said mixture.

A treatment method of at least partially removing impurities from a composition containing a fluorine-containing organic acid having the carbon number of 2 to 7 and impurities, the method including a flocculant mixing step of mixing the composition and a flocculant; and a separating step of separating a mixed phase obtained at the mixing step into a solid phase and a liquid phase.

A treatment method of at least partially removing impurities from a composition containing a fluorine-containing organic acid having the carbon number of 2 to 7 and impurities, the method including a flocculant mixing step of mixing the composition and a flocculant; and a separating step of separating a mixed phase obtained at the mixing step into a solid phase and a liquid phase.

A process for preparing a compound of formula (I) HR.sup.1R.sup.2CCF.sub.2(C?O)Y starting with a compound of formula (II) R.sup.1R.sup.2C?CX(C?O)Y or of formula (III) HR.sup.1R.sup.2CCX.sup.1X.sup.2(C?O)Y placed in contact with hydrofluoric acid; R.sup.1 and R.sup.2 being independently selected from H, F, Cl, Br, I, C.sub.1-C.sub.20-alkyl, C.sub.6-C.sub.20-aryl and C.sub.2-C.sub.20-alkenyl, C.sub.3-C.sub.20-cycloalkenyl and C.sub.3-C.sub.20-cycloalkyl; X.sup.1 and X.sup.2 being independently selected from F, Cl, Br and I on condition that X.sup.1 and X.sup.2 are not simultaneously F; Y being selected from the group of H, C.sub.1-C.sub.20-alkyl, C.sub.1-C.sub.20-haloalkyl, C.sub.6-C.sub.20-aryl, OH, OR, NH.sub.2, NHR, NR.sub.2, SR, C.sub.3-C.sub.20-cycloalkyl, C.sub.3-C.sub.20-cycloalkenyl and C.sub.2-C.sub.20-alkenyl; R being independently selected from the group of C.sub.1-C.sub.20-alkyl, C.sub.6-C.sub.20-aryl and C.sub.2-C.sub.20-alkenyl, C.sub.3-C.sub.20-cycloalkenyl and C.sub.3-C.sub.20-cycloalkyl.

A process for preparing a compound of formula (I) HR.sup.1R.sup.2CCF.sub.2(C?O)Y starting with a compound of formula (II) R.sup.1R.sup.2C?CX(C?O)Y or of formula (III) HR.sup.1R.sup.2CCX.sup.1X.sup.2(C?O)Y placed in contact with hydrofluoric acid; R.sup.1 and R.sup.2 being independently selected from H, F, Cl, Br, I, C.sub.1-C.sub.20-alkyl, C.sub.6-C.sub.20-aryl and C.sub.2-C.sub.20-alkenyl, C.sub.3-C.sub.20-cycloalkenyl and C.sub.3-C.sub.20-cycloalkyl; X.sup.1 and X.sup.2 being independently selected from F, Cl, Br and I on condition that X.sup.1 and X.sup.2 are not simultaneously F; Y being selected from the group of H, C.sub.1-C.sub.20-alkyl, C.sub.1-C.sub.20-haloalkyl, C.sub.6-C.sub.20-aryl, OH, OR, NH.sub.2, NHR, NR.sub.2, SR, C.sub.3-C.sub.20-cycloalkyl, C.sub.3-C.sub.20-cycloalkenyl and C.sub.2-C.sub.20-alkenyl; R being independently selected from the group of C.sub.1-C.sub.20-alkyl, C.sub.6-C.sub.20-aryl and C.sub.2-C.sub.20-alkenyl, C.sub.3-C.sub.20-cycloalkenyl and C.sub.3-C.sub.20-cycloalkyl.

The present invention pertains generally to the field of imaging compounds, and more specifically to certain 2,2-dialkyl radionuclide-labelled carboxylic acids suitable for PET, SPECT and/or DNP imaging. Also described are used of such compounds in the imaging of inter alia, cancer tumours, metastasis, Alzheimer's disease and multiple sclerosis.

The present invention pertains generally to the field of imaging compounds, and more specifically to certain 2,2-dialkyl radionuclide-labelled carboxylic acids suitable for PET, SPECT and/or DNP imaging. Also described are used of such compounds in the imaging of inter alia, cancer tumours, metastasis, Alzheimer's disease and multiple sclerosis.

The present invention generally relates to processes for converting acrylate esters or a derivative thereof to difluoropropionic acid or a derivative thereof. This process is generally performed using fluorine gas in a hydrofluorocarbon solvent.

The present invention generally relates to processes for converting acrylate esters or a derivative thereof to difluoropropionic acid or a derivative thereof. This process is generally performed using fluorine gas in a hydrofluorocarbon solvent.