Crystalline forms of 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide (Compound I) were prepared and characterized in the solid state:

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Also provided are processes of manufacture and methods of using the crystalline forms.

Crystalline forms of 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide (Compound I) were prepared and characterized in the solid state:

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Also provided are processes of manufacture and methods of using the crystalline forms.

The present invention provides a salt form and compositions thereof, which are useful as an inhibitor of EGFR kinases and which exhibits desirable characteristics for the same.

The present invention provides a salt form and compositions thereof, which are useful as an inhibitor of EGFR kinases and which exhibits desirable characteristics for the same.

The present disclosure relates to free base and salt crystals of 2-(4-acetylbenzyl)-3-((4-fluorophenyl)amino)-5,7,7-trimethyl-7,8-dihydro-2H-imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(5H)-one, composition comprising the same and the method of making and using such free base and salt crystals.

Processes for producing cesium oxalate are disclosed. The process includes contacting cesium carbonate, cesium hydrogenbicarbonate or a mixture thereof with carbon dioxide and carbon monoxide, carbon dioxide and hydrogen or carbon monoxide and oxygen at elevenated temperatures and pressures.

Processes for producing cesium oxalate are disclosed. The process includes contacting cesium carbonate, cesium hydrogenbicarbonate or a mixture thereof with carbon dioxide and carbon monoxide, carbon dioxide and hydrogen or carbon monoxide and oxygen at elevenated temperatures and pressures.

Processes for producing cesium oxalate are disclosed. The process includes contacting cesium carbonate, cesium hydrogenbicarbonate or a mixture thereof with carbon dioxide and carbon monoxide, carbon dioxide and hydrogen or carbon monoxide and oxygen at elevenated temperatures and pressures.

A method of selectively removing impurities from a scandium-containing feed solution includes contacting an aqueous scandium-containing solution with an organic solvent stream containing an extractant, thereby forming a loaded organic solvent stream containing the impurity or impurities while leaving the scandium in the raffinate. The aqueous stream containing the scandium is washed, diluted and has inorganic salts added before being contacted with a second organic solvent stream to extract the scandium selectively, and followed by stripping the scandium from the scandium-containing loaded organic extractant stream by adding oxalic acid to the loaded organic extractant stream to form scandium oxalate.

A method of selectively removing impurities from a scandium-containing feed solution includes contacting an aqueous scandium-containing solution with an organic solvent stream containing an extractant, thereby forming a loaded organic solvent stream containing the impurity or impurities while leaving the scandium in the raffinate. The aqueous stream containing the scandium is washed, diluted and has inorganic salts added before being contacted with a second organic solvent stream to extract the scandium selectively, and followed by stripping the scandium from the scandium-containing loaded organic extractant stream by adding oxalic acid to the loaded organic extractant stream to form scandium oxalate.