Provided herein are novel polymorphic forms and co-crystals of a compound useful in the treatment, prevention, or amelioration of cancer. In particular, the invention provides polymorphs and co-crystals of 6-{(1R)-1-[8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one, which is an inhibitor of c-Met.

Provided herein are novel polymorphic forms and co-crystals of a compound useful in the treatment, prevention, or amelioration of cancer. In particular, the invention provides polymorphs and co-crystals of 6-{(1R)-1-[8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one, which is an inhibitor of c-Met.

The present invention discloses a method of producing potassium sorbate particles, comprising the steps of: (1) preparing a potassium sorbate solution; (2) spray drying; (3) spray forming; (4) indirectly drying with steam on a vibration fluidized bed; and (5) swing-type sifting; in step (3), a binder is obtained by spray drying after adding sorbitol to the potassium sorbate solution prepared in step (1), and the binder is mixed with the potassium sorbate powder obtained by spray drying in step (2) to undergo the spray forming process; based on weight ratio, the weight ratio of the sorbitol required to prepare the binder to the potassium sorbate solution required to prepare the binder is 0.05-0.1%:1. The beneficial effects of the present invention are: an appropriate binding effect of the powder particles, a good breaking effect and a good spheronization effect of the powder particles, and uniformity of granulation.

The present invention discloses a method of producing potassium sorbate particles, comprising the steps of: (1) preparing a potassium sorbate solution; (2) spray drying; (3) spray forming; (4) indirectly drying with steam on a vibration fluidized bed; and (5) swing-type sifting; in step (3), a binder is obtained by spray drying after adding sorbitol to the potassium sorbate solution prepared in step (1), and the binder is mixed with the potassium sorbate powder obtained by spray drying in step (2) to undergo the spray forming process; based on weight ratio, the weight ratio of the sorbitol required to prepare the binder to the potassium sorbate solution required to prepare the binder is 0.05-0.1%:1. The beneficial effects of the present invention are: an appropriate binding effect of the powder particles, a good breaking effect and a good spheronization effect of the powder particles, and uniformity of granulation.

The present invention discloses a method of producing potassium sorbate particles, comprising the steps of: (1) preparing a potassium sorbate solution; (2) spray drying; (3) spray forming; (4) indirectly drying with steam on a vibration fluidized bed; and (5) swing-type sifting; in step (3), a binder is obtained by spray drying after adding sorbitol to the potassium sorbate solution prepared in step (1), and the binder is mixed with the potassium sorbate powder obtained by spray drying in step (2) to undergo the spray forming process; based on weight ratio, the weight ratio of the sorbitol required to prepare the binder to the potassium sorbate solution required to prepare the binder is 0.05-0.1%:1. The beneficial effects of the present invention are: an appropriate binding effect of the powder particles, a good breaking effect and a good spheronization effect of the powder particles, and uniformity of granulation.

Provided herein are novel polymorphic forms and co-crystals of a compound useful in the treatment, prevention, or amelioration of cancer. In particular, the invention provides polymorphs and co-crystals of 6-{(1R)-1-[8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one, which is an inhibitor of c-Met.

Provided herein are novel polymorphic forms and co-crystals of a compound useful in the treatment, prevention, or amelioration of cancer. In particular, the invention provides polymorphs and co-crystals of 6-{(1R)-1-[8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one, which is an inhibitor of c-Met.

Zinc and copper (II) salts of the general formula CH.sub.2C(R.sup.1)COO-M-OCOR.sup.2 are disclosed, wherein M-Zn or Cu, R.sup.1H or CH.sub.3, R.sup.2C.sub.2-C.sub.25 alkyl, or R.sup.2COO group is crotonate, or sorbate, or linoleate, excluding the compounds: CH.sub.2C(CH.sub.3)COOZnOCOC.sub.2H.sub.5, CH.sub.2CHCOOZnOCOC.sub.2H.sub.5, CH.sub.2CHCOOCuOCOC.sub.2H.sub.5, CH.sub.2C(CH.sub.3)COOZnOCO(CH.sub.2).sub.4CH.sub.3, CH.sub.2CHCOOZnOCO(CH.sub.2).sub.4CH.sub.3, CH.sub.2CHCOOZnOCO(CH.sub.2).sub.6CH.sub.3, CH.sub.2C(CH.sub.3)COOZnOCO(CH.sub.2).sub.6CH.sub.3, CH.sub.2CHCOOCuOCO(CH.sub.2).sub.6CH.sub.3, CH.sub.2CHCOOZnOCO(CH.sub.2).sub.14CH.sub.3, CH.sub.2C(CH.sub.3)COOZnOCO(CH.sub.2).sub.16CH.sub.3, CH.sub.2C(CH.sub.3)COOZnOCO-iso-C.sub.17H.sub.35, CH.sub.2CHCOOZnOCO-iso-C.sub.17H.sub.35, CH.sub.2C(CH.sub.3)COOZnOCO(CH.sub.2).sub.17CH.sub.3. Salts of the general formula wherein R.sup.2C.sub.2-C.sub.25 alkyl, or R.sup.2COO group is crotonate, or sorbate, or linoleate, are applicable as biocides.

Zinc and copper (II) salts of the general formula CH.sub.2C(R.sup.1)COO-M-OCOR.sup.2 are disclosed, wherein M-Zn or Cu, R.sup.1H or CH.sub.3, R.sup.2C.sub.2-C.sub.25 alkyl, or R.sup.2COO group is crotonate, or sorbate, or linoleate, excluding the compounds: CH.sub.2C(CH.sub.3)COOZnOCOC.sub.2H.sub.5, CH.sub.2CHCOOZnOCOC.sub.2H.sub.5, CH.sub.2CHCOOCuOCOC.sub.2H.sub.5, CH.sub.2C(CH.sub.3)COOZnOCO(CH.sub.2).sub.4CH.sub.3, CH.sub.2CHCOOZnOCO(CH.sub.2).sub.4CH.sub.3, CH.sub.2CHCOOZnOCO(CH.sub.2).sub.6CH.sub.3, CH.sub.2C(CH.sub.3)COOZnOCO(CH.sub.2).sub.6CH.sub.3, CH.sub.2CHCOOCuOCO(CH.sub.2).sub.6CH.sub.3, CH.sub.2CHCOOZnOCO(CH.sub.2).sub.14CH.sub.3, CH.sub.2C(CH.sub.3)COOZnOCO(CH.sub.2).sub.16CH.sub.3, CH.sub.2C(CH.sub.3)COOZnOCO-iso-C.sub.17H.sub.35, CH.sub.2CHCOOZnOCO-iso-C.sub.17H.sub.35, CH.sub.2C(CH.sub.3)COOZnOCO(CH.sub.2).sub.17CH.sub.3. Salts of the general formula wherein R.sup.2C.sub.2-C.sub.25 alkyl, or R.sup.2COO group is crotonate, or sorbate, or linoleate, are applicable as biocides.

The present invention discloses a method of producing potassium sorbate particles, comprising the steps of: (1) preparing a potassium sorbate solution; (2) spray drying; (3) spray forming; (4) indirectly drying with steam on a vibration fluidized bed; and (5) swing-type sifting; in step (3), a binder is obtained by spray drying after adding sorbitol to the potassium sorbate solution prepared in step (1), and the binder is mixed with the potassium sorbate powder obtained by spray drying in step (2) to undergo the spray forming process; based on weight ratio, the weight ratio of the sorbitol required to prepare the binder to the potassium sorbate solution required to prepare the binder is 0.05-0.1%:1.

The beneficial effects of the present invention are: an appropriate binding effect of the powder particles, a good breaking effect and a good spheronization effect of the powder particles, and uniformity of granulation.