The invention discloses a method for preparing maleate by selective catalytic oxidation of lignin. The method uses a heteropolyacid functionalized ionic liquid as a catalyst, and an aqueous alcohol solution as a reaction medium to achieve high-efficiency selective catalytic conversion and ring opening oxidation of biomass lignin at a reaction temperature of 110-160 C. and an oxygen pressure of 0.5-1.0 MPa for 1-6 h. The selectivity of maleate is higher than 47.83%. The yield and selectivity of a single chemical derived from the depolymerization of lignin in the present invention are much higher than the prior art, and the ionic liquid catalyst exhibits outstanding advantages such as availability of recovery and recycling through simple temperature adjustment; the reaction conditions of the present invention are mild, and the process is green and safe, easy to operate, and available forbatch and continuous production. The invention provides a new green way for preparing bulk chemicals like maleate from reproducible raw materials such as lignin.

The invention discloses a method for preparing maleate by selective catalytic oxidation of lignin. The method uses a heteropolyacid functionalized ionic liquid as a catalyst, and an aqueous alcohol solution as a reaction medium to achieve high-efficiency selective catalytic conversion and ring opening oxidation of biomass lignin at a reaction temperature of 110-160 C. and an oxygen pressure of 0.5-1.0 MPa for 1-6 h. The selectivity of maleate is higher than 47.83%. The yield and selectivity of a single chemical derived from the depolymerization of lignin in the present invention are much higher than the prior art, and the ionic liquid catalyst exhibits outstanding advantages such as availability of recovery and recycling through simple temperature adjustment; the reaction conditions of the present invention are mild, and the process is green and safe, easy to operate, and available forbatch and continuous production. The invention provides a new green way for preparing bulk chemicals like maleate from reproducible raw materials such as lignin.

The present disclosure relates to pouches made from a combination of chemically different water-soluble films and optionally containing a composition (e.g. a household care composition or non-household care composition) that is at least partially enclosed by the water-soluble films in at least one compartment.

The present disclosure relates to pouches made from a combination of chemically different water-soluble films and optionally containing a composition (e.g. a household care composition or non-household care composition) that is at least partially enclosed by the water-soluble films in at least one compartment.

Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.

Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.

Provided are salts of 2, 6-dimethylpyrimidone derivatives and uses thereof. Also provided are pharmaceutical compositions containing the salts.

Provided are salts of 2, 6-dimethylpyrimidone derivatives and uses thereof. Also provided are pharmaceutical compositions containing the salts.

A salt of a quinazoline derivative (N-[4-(3-chlorine-4-fluoanilino)]-7-(3-morpholinepropanol)-6-(2-fluoroacrylamide)-quinazoline, the structure thereof is as represented by formula I). Compared with a known quinazoline derivative, the salt of the quinazoline derivative has one or more improved properties and at least has better water solubility, wherein a citrate, a benzene sulfonate, and an ethanedisulphonate thereof further have better crystallinity and are not easy to absorb moisture.

##STR00001##

A salt of a quinazoline derivative (N-[4-(3-chlorine-4-fluoanilino)]-7-(3-morpholinepropanol)-6-(2-fluoroacrylamide)-quinazoline, the structure thereof is as represented by formula I). Compared with a known quinazoline derivative, the salt of the quinazoline derivative has one or more improved properties and at least has better water solubility, wherein a citrate, a benzene sulfonate, and an ethanedisulphonate thereof further have better crystallinity and are not easy to absorb moisture.

##STR00001##