The present invention provides solid forms of compound (1) and compositions thereof which are useful as inhibitors of Plasma Kallikrein (pKal) and which exhibit desirable characteristics for the same.

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The present invention provides solid forms of compound (1) and compositions thereof which are useful as inhibitors of Plasma Kallikrein (pKal) and which exhibit desirable characteristics for the same.

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The present invention relates to salts of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane, to methods for making them or their precursors, to pharmaceutical compositions comprising them, and to their use as medicaments.

The present invention relates to salts of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane, to methods for making them or their precursors, to pharmaceutical compositions comprising them, and to their use as medicaments.

A method of production of malic acid includes treating a first intermediate product to form a second intermediate product. The treating includes substantially removing impurities from the first intermediate product to obtain a treated intermediate product by gas stripping the crude maleic anhydride, or subjecting a mixture of one or more of the crude maleic acid, the crude fumaric acid, and the vent gas scrubber solution obtained from a phthalic anhydride production process or a maleic anhydride production process to crystallization, passing an aqueous solution of the treated intermediate product through a carbon column to substantially remove retained impurities to form the second intermediate product, obtaining a feed that includes the second intermediate product, and causing the feed to undergo hydration reaction in a tubular reactor or a continuous stirred tank reactor to produce malic acid.

A method of production of malic acid includes treating a first intermediate product to form a second intermediate product. The treating includes substantially removing impurities from the first intermediate product to obtain a treated intermediate product by gas stripping the crude maleic anhydride, or subjecting a mixture of one or more of the crude maleic acid, the crude fumaric acid, and the vent gas scrubber solution obtained from a phthalic anhydride production process or a maleic anhydride production process to crystallization, passing an aqueous solution of the treated intermediate product through a carbon column to substantially remove retained impurities to form the second intermediate product, obtaining a feed that includes the second intermediate product, and causing the feed to undergo hydration reaction in a tubular reactor or a continuous stirred tank reactor to produce malic acid.

The present invention relates to co-crystals, salts and crystalline forms of tenofovir alafenamide and methods for preparation, use and isolation of such compounds.

The present invention relates to co-crystals, salts and crystalline forms of tenofovir alafenamide and methods for preparation, use and isolation of such compounds.

Solid state forms of Valbenazine, Valbenazine salts, processes for preparation thereof and pharmaceutical compositions thereof are disclosed. Processes for the preparation of Valbenazine and intermediates in the preparation thereof are further described.

Solid state forms of Valbenazine, Valbenazine salts, processes for preparation thereof and pharmaceutical compositions thereof are disclosed. Processes for the preparation of Valbenazine and intermediates in the preparation thereof are further described.