Patent classifications
C07C59/31
TREPROSTINIL DERIVATIVE COMPOUNDS AND METHODS OF USING SAME
Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
Treprostinil derivative compounds and methods of using same
Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
Treprostinil derivative compounds and methods of using same
Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
TREPROSTINIL DERIVATIVE COMPOUNDS AND METHODS OF USING SAME
Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
TREPROSTINIL DERIVATIVE COMPOUNDS AND METHODS OF USING SAME
Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
COMPOSITIONS AND METHODS RELATED TO HALF SALTS OF HERBICIDAL CARBOXYLIC ACIDS
Half salts of certain synthetic auxin herbicides are provided. These half salts are useful for controlling unwanted plant growth. The half salts have low solubility in water, low volatility relative to commercial compositions of the corresponding synthetic auxin herbicides, and offer comparable herbicidal performance when compared to existing salts of the synthetic auxin herbicides.
COMPOSITIONS AND METHODS RELATED TO HALF SALTS OF HERBICIDAL CARBOXYLIC ACIDS
Half salts of certain synthetic auxin herbicides are provided. These half salts are useful for controlling unwanted plant growth. The half salts have low solubility in water, low volatility relative to commercial compositions of the corresponding synthetic auxin herbicides, and offer comparable herbicidal performance when compared to existing salts of the synthetic auxin herbicides.
Composition for resin raw material
In order to improve resin physical properties such as heat resistance (glass transition temperature) of a resin such as polyester obtained from 2,2-bis(carboxymethoxy)-1,1-binaphthyl, provided is a composition for a resin raw material containing a compound represented by formula (1) as a component A and a compound represented by formula (2) as a component B, wherein their composition ratios are in ranges wherein the component A is present in an amount of 98.0 area % or more and 99.99 area % or less, and the component B is present in an amount of 1.50 area % or less, relative to the total amount of all components detected at a wavelength of 280 nm by high-performance liquid chromatography analysis using a UV detector. ##STR00001##
Composition for resin raw material
In order to improve resin physical properties such as heat resistance (glass transition temperature) of a resin such as polyester obtained from 2,2-bis(carboxymethoxy)-1,1-binaphthyl, provided is a composition for a resin raw material containing a compound represented by formula (1) as a component A and a compound represented by formula (2) as a component B, wherein their composition ratios are in ranges wherein the component A is present in an amount of 98.0 area % or more and 99.99 area % or less, and the component B is present in an amount of 1.50 area % or less, relative to the total amount of all components detected at a wavelength of 280 nm by high-performance liquid chromatography analysis using a UV detector. ##STR00001##
Multi-arm single molecular weight polyethylene glycol active derivative and application thereof
Being used for drug modification, the multi-arm single molecular weight polyethylene glycol active derivative provided herein can effectively improve the solubility, stability, and immunogenicity of the drugs, improve the absorption of the drugs in vivo, prolong the half-life of the drugs, and increase bioavailability, enhance efficacy, and reduce toxic and side effects of the drugs. A gel formed from the multi-arm single molecular weight polyethylene glycol active derivative provided herein can be used for the preparation of controlled release drugs so as to prolong the action time of the drugs, thereby reducing the number of administrations and improving patient compliance.