Introduced here is an ingestible device comprising a capsule having a central axis therethrough, at least one propulsion component, and at least one motor configured to supply motive power to the propulsion component(s). The propulsion component(s) may be disposed at locations radially offset from the central axis. Upon receiving input indicative of a request to alter a position and/or an orientation of the ingestible device, the motor(s) can supply motive power to some or all of the propulsion component(s) to cause movement of the ingestible device.

Introduced here is an ingestible device comprising a capsule, a camera, an antenna, and a propulsion component. The camera can capture images of various in vivo environments as the ingestible device traverses the gastrointestinal tract, and these images can be wirelessly transmitted to an electronic device located outside of the living body. The images may be transmitted to the electronic device for review by an operator responsible for controlling the ingestible device.

Introduced here is an ingestible device that can comprise a capsule, an intervention tool, and a processor configured to controllably employ the intervention tool to manipulate structures in a living body. The ingestible device may further comprise a camera that is configured to generate images of various in vivo environments as the ingestible device traverses the living body. These images may be wirelessly transmitted to an electronic device located outside of the living body to enable greater control over the intervention tool.

Example embodiments relate to endoscopic systems. Endoscopic system includes main body and control section. Control section includes extendible section that extends and contracts to change length between extendible section ends. Control section includes first expandable member. When first expandable member is in an expanded configuration, first expandable member includes proximal side wall and distal side wall. Distal side wall of first expandable member includes first protrusions. Control section includes second expandable member. When second expandable member is in an expanded configuration, second expandable member includes distal side wall and proximal side wall. Proximal side wall of second expandable member includes second protrusions. First and second protrusions configurable to cooperate to form a sieve portion between first and second expandable members. The sieve portion configured to reduce an occurrence of solids blocking pressure openings while allowing negative pressure to be applied to a body cavity wall through the pressure openings.

Example embodiments relate to endoscopic systems. The system includes an outer assembly and main assembly. The outer assembly may include proximal and distal ends and outer anchor assembly. The outer anchor assembly may include a first expandable member and first outer pressure opening. The first expandable member may expand radially outwards. The main assembly may include proximal and distal ends and a navigation assembly. The navigation assembly may include an instrument, second expandable member, bendable section, extendible section, and first pressure opening. The extendible section may include proximal and distal ends. The proximal end of the extendible section may be secured in position relative to the distal end of the outer assembly. The extendible section may be configurable to extend and contract. The first main pressure opening may be configurable to apply a negative pressure.

In some embodiment, the present invention is directed to a device for obtaining samples from a subject. In other embodiments, methods and devices of the present invention allow the evaluation of conditions of the gastrointestinal tract of a subject. Measurements may be utilized, for example, to diagnose a disease of the esophagus, to monitor inflammation of the esophagus, or to access the treatment of a disease of the esophagus. In one embodiment, the invention comprises a method for measuring esophageal inflammation comprising deploying a device into the esophagus of a subject, removing the device after a predetermined period of time, analyzing the device for a diagnostic indicator of esophageal inflammation and evaluating the diagnostic indicator to diagnose esophageal inflammation.

A self-propelled semi- or fully-autonomous robotic endoscope device is provided that include multi-degrees of freedom movement and may be sensor-enabled for colonoscopy procedures. The device may include two independently controlled motors configured to drive micro-pillared treads above and below the device, allowing for 2-degrees of freedom (DOF) skid-steering even in a collapsed lumen. The robotic device contains similar functionality of a traditional endoscope, such as a camera, adjustable LEDs, channels for insufflation and irrigation, and a tool port for common endoscopy instruments (e.g., forceps, snares, etc.).

In some embodiments, devices, systems, and methods for advancing and positioning tethered capsule microendoscopes are provided. In some embodiments, a device for capsule endomicroscopy is provided, comprising: a tether having a proximal end and distal end; an optical fiber disposed within the tether; a tube enclosing at least a portion of the tether, the tube having a proximal end and a distal end, a diameter of the tube being larger than the diameter of the tether; a housing coupled to the distal end of the tether and the distal end of the tube; and an optical element disposed within the housing, the optical element being optically coupled to the distal end of the optical fiber and configured to direct light received from the optical fiber toward a periphery of the housing.

A tubular connector for use with a spiral tube used on an insertion section of an endoscope. The tubular connector including: an outer surface; an inner surface; and a plurality of cams circumferentially spaced on the inner surface to project radially inward from the inner surface, the plurality of cams extending in a longitudinal direction of the tubular connector; wherein each of the plurality of cams have one or more cam surfaces configured to engage a rotating member to rotate the spiral tube. The plurality of cams can alternatively be formed directly on an interior surface of the spiral tube.

Devices, including robotic devices, operating in viscous fluid flow can use passive sensor data collected to represent fluid parameters at an instant in time to derive information about the flow, the motion and position of the device, and parameters of the physical system constraining the flow. Using quasi-static analysis techniques, and appropriate feature selection for machine learning, very accurate determinations can be made, generally in real time, with very modest computational requirements. These determinations can then be used to map systems, navigate devices through a system, or otherwise control the actions of, e.g., robotic devices for clean-up, leak detection, or other functions.