The methods and apparatus of the present invention allow the evaluation of inflammation of the esophagus. Measurements may be utilized, for example, to diagnose a disease of the esophagus, to monitor inflammation of the esophagus, or to access the treatment of a disease of the esophagus. In one embodiment, the invention comprises a method for measuring esophageal inflammation comprising deploying a device into the esophagus of a subject, removing the device after a predetermined period of time, analyzing the device for a diagnostic indicator of esophageal inflammation and evaluating the diagnostic indicator to diagnose esophageal inflammation.

The present invention discloses a capsule endoscope with specific gravity control. The capsule endoscope comprises a housing to enclose various components, an inflatable device attached to a first longitudinal end of the capsule unit and an enteric coated shell attached to the first longitudinal end of the capsule unit to enclose the inflatable device between the enteric coated shell and the capsule unit. The various components include a camera sub-system for capturing image frames. The inflatable device comprises an inflatable membrane and an effervescent formulation inside the inflatable membrane. The enteric coated shell fits tightly onto the first longitudinal end of the capsule unit to prevent body liquid from leaking into a space between the enteric coated shell and the capsule unit when the capsule unit travels in human gastrointestinal tract after being swallowed.

An insertion device includes a thin and elongated insertion section, a rotating body which is rotated to advance or retreat the insertion section, a driving force supply source which supplies a driving force to the rotating body, a variable stiffness section provided for the insertion section and permitting stiffness of the insertion section to be varied, a stiffness detector which detects the stiffness of the insertion section varied by the variable stiffness section, and a controller which controls the driving force supply source in accordance with the stiffness of the insertion section detected by the stiffness detector.

A self-propelled endoscope apparatus includes a rotation body, a motor, a drive circuit, and a regeneration protection circuit. The rotation body is provided on an outer peripheral surface of an elongated insertion section. The rotation body is configured to be rotatable. The motor rotates the rotation body. The drive circuit drives the motor. The regeneration protection circuit performs protecting operation for protecting the drive circuit from regeneration voltage generated by regeneration of the motor.

A system for propelling a magnetic robotic device through a human comprises a magnetic actuator device operable to generate a rotating magnetic field, and a magnetic robotic device comprising a compliant body and at least two permanent magnets supported by and spatially separated about the compliant body. A non-magnetic region can also be oriented between the at least two permanent magnets. The at least two permanent magnets can be alternating or non-alternating in polarity with each other. In response to application of the rotating magnetic field generated by the magnetic actuator device and that is situated proximate the magnetic robotic device, the rotating magnetic field effectuates undulatory locomotion of the magnetic robotic device to propel the magnetic robotic device through a human, such as through a natural lumen. Further, the magnetic robotic device can optionally be supported by a catheter or endoscope to assist with propelling a distal end through a human.

An apparatus includes a rotation body, a motor, a drive controller, a rotating speed detector, a rotation error determination circuit, and a filter. The rotation body is provided on an outer peripheral surface of an elongated insertion section and configured to be rotatable around a longitudinal axis. The motor rotates the rotation body. The drive controller controls driving of the motor. The rotating speed detector detects a rotating speed of the motor based on an encoder signal output from an encoder. The rotation error determination circuit determines an error in rotation of the rotation body based on the detected rotating speed. The filter passes, as the encoder signal, only a signal having a frequency, outside a frequency band of a high-frequency signal of a high-frequency treatment instrument, of signals input to the rotating speed detector.

A locomotion system for use in a medical device, including at least one magnet, a rotor including a plurality of coil windings, and a ferromagnetic member. The rotor is configured, on application of a current to the plurality of coil windings, to travel along the ferromagnetic member and to impact on a surface.

A controller which controls an operation of a self-propelled mechanism of an endoscope includes an inspection control section, a usual control section, an endoscope connection detection circuit and a control switch section. The endoscope connection detection circuit detects that the endoscope has been connected. The control switch section determines whether or not the inspection operation is performed for the endoscope at the time of the connection of the endoscope, causes the usual control section to perform the usual operation when the inspection operation is performed, and causes the inspection control section to perform the inspection operation and then causes the usual control section to perform the usual operation when the inspection operation is not performed.

A self-propelled device for locomotion through a lumen, comprising a set of serially arranged inflatable chambers, the end ones of which expand at least radially when inflated. Connecting passages provide fluid communication between each pair of adjacent chambers. A fluid source is attached to one of the end chambers. The connecting passages are such that the fluid inflates the chambers in a sequence, beginning with the chamber closest to the source, and ending with the chamber furthest from the source. The same sequence occurs when the chambers deflate, beginning with the chamber closest to the source, and ending with the chamber furthest from the source. The fluid source can either be a fluid supply tube, extending to a supply outside the lumen, or it can be built-in and carried by the device. The device can crawl either along the lumen wall or on an inserted guide wire.

A self-propelled device for locomotion through a lumen, comprising a set of serially arranged inflatable chambers, adjacent chambers being fluidly connected, and a fluid source attached to one end of the set, such that the chambers inflate sequentially. The chambers are constructed of an elastic material and have a wall thickness and dimensions such that they have a characteristic with a non-monotonous relationship between the inflation pressure within the chamber and the chamber's inflated size. The characteristic is such that after an initial inflation pressure peak, the non-monotonous relationship adopts a negative slope, such that the volume of the chamber increases more rapidly than the volume of fluid flowing into it, and the inflation pressure of the chamber falls. This effect causes the chamber to inflate and anchor rapidly, while essentially slowing down the inflation of the succeeding chamber until inflation of the first is complete.