A treatment method and a treatment system capable of effectively irradiating an antibody-photosensitive substance bound to a tumor cell with a near-infrared ray. The treatment method for irradiating the antibody-photosensitive substance bound to the tumor cell membrane in the tumor cell with the near-infrared ray includes: intravenously administering the antibody-photosensitive substance; percutaneously puncturing a tumor or a vicinity of the tumor with a hollow outer needle, while percutaneously acquiring and checking an ultrasound image; making an inner needle having a plurality of sharp inner needle tips protrude from the outer needle, and puncturing the tumor or the vicinity of the tumor with the inner needle tips; and irradiating the antibody-photosensitive substance bound to the tumor cell membrane with the near-infrared ray from an optical fiber inserted into the inner needle after 12 hours to 36 hours from the intravenous administration.

A manufacturing method for an image pickup apparatus for endoscope includes forming a plurality of insertion holes in a first wafer and forming, in a second wafer, a plurality of through-holes including guide surfaces, bonding the first wafer and the second wafer to produce a bonded wafer, cutting the bonded wafer to thereby produce ferrules to which guide members are bonded, and mounting an optical element on each of the ferrules and fixing optical fibers with resin in a state in which the optical fibers are inserted into the insertion holes by passing through the guide members.

An imaging probe comprises a camera or endoscope with an external detector array, in which the probe is sized and shaped for surgical placement in an eye to image the eye from an interior of the eye during treatment. The imaging probe and a treatment probe can be coupled together with a fastener or contained within a housing. The imaging probe and the treatment probe can be sized and shaped to enter the eye through an incision in the cornea and image one or more of the ciliary body band or the scleral spur. The treatment probe may comprise a treatment optical fiber or a surgical placement device to deliver an implant. A processor coupled to the detector can be configured with instructions to identify a location of one or more of the ciliary body band, the scleral spur, Schwalbe's line, or Schlemm's canal from the image.

A light emitting device includes a light source configured to emit a primary light, a first phosphor that absorbs the primary light and converts the primary light into a first wavelength-converted light having a wavelength longer than that of the primary light, and a second phosphor that absorbs the primary light and converts the primary light into a second wavelength-converted light having a wavelength longer than that of the primary light. The first wavelength-converted light is a fluorescence having a light component over an entire wavelength range of 700 nm or more to 800 nm or less. The second wavelength-converted light is a fluorescence having a peak where a fluorescence intensity shows a maximum value in a wavelength range of 380 nm or more to less than 700 nm. The first wavelength-converted light has a 1/10 afterglow time longer than that of the second wavelength-converted light.

A light source for illuminating a target for medical imaging include a first light emitter package comprising a first light emitter that emits light having a first wavelength band and a second light emitter that emits light having a second wavelength band that is different than the first wavelength band; and a controller for operating the light source in a first mode in which the first light emitter is activated and the second light emitter is deactivated and a second mode in which the first light emitter is deactivated and the second light emitter is activated.

Treated ends of optical fibers for use in an endoscope are disclosed. An end of an optical fiber, either raw cut or polished, is coated with an optical material that enables the end to be aligned without the need for conventional flush mounting techniques.

There is provided a new apparatus, system, and method of use for laser speckle imaging that allows for omni-directional viewing. The omni-directional viewing can include a reflector and switches configured for switching the illumination on the luminal tissue such that the light reflected from the luminal tissue at any given time is reflected from one or more substantially non-overlapping sections of a luminal tissue. This apparatus may be particularly useful for tissue analysis such as analysis of vulnerable plaque.

An integrated guidewire includes a wire and a flexible tube. The wire is sized and shaped to move in an anatomical material transportation system of a patient. The flexible tube is sized and shaped to move in the anatomical material transportation system, having proximal and distal ends, the proximal-end is coupled to a device external to the patient, the flexible tube is configured to transfer fluids between the distal-end and the device, and the wire and the flexible tube are intertwined with respect to one another.

An optical module for endoscope includes an optical element, an optical fiber, a ferrule including a first principal surface, a second principal surface, and a side surface, an opening of an insertion hole being present on the first principal surface, the insertion hole having a bottom surface made of a transparent material, the optical fiber being inserted into the insertion hole, the optical element being bonded to the second principal surface, an opening of a groove connected to the insertion hole being present on the first principal surface, the grove having a bottom surface made of the transparent material, and transparent resin disposed in the insertion hole and the groove of the ferrule.

A drive assembly for driving an imaging catheter has a rotatable fiber and a rotatable drive shaft. The drive assembly includes a fiber optic rotating junction and a motor configured to rotate the rotatable portion of the fiber optic rotating junction. In some embodiments, the drive assembly includes a sensor configured to detect a rotational position of the fiber optic rotating junction and a processor configured to obtain the detected rotational position and stop the motor only when the fiber optic rotating junction is in a predetermined rotational position. In some embodiments, the motor includes a hollow shaft through which at least a portion of the fiber optic rotating junction extends.