An optical endoluminal far-field microscopic imaging catheter comprises a light generating system, a first light delivery conduit for propagating light generated by the light generating system and a light distributor configured to redirect light propagated by the delivery conduit into a direction of an object to be imaged. A discriminator is configured for capturing light reflected from the object incident on a window of the discriminator from a particular direction and transmitting only the light captured from the particular direction to a second light delivery conduit. A drive mechanism is configured to sweep the window through a plurality of directions in a predictable pattern for matching each light capture event in the window with a direction of the window during the event. An analyzer matches the direction of the window with an associated light capture event and generate a visible image based on a mosaic of the captured light.

The present invention relates to nanoparticles, a preparation method thereof, a stone removal device, a magnetic target separation instrument and its application. The nanoparticles include a nanoparticle core made of magnetic materials, and a nanoparticle shell formed by attaching surface modifier monomers to the nanoparticle core with an initiator and/or a crosslinking agent. The prepared nanoparticles can wrap stones in ureter, and then small stones remaining in body can be removed quickly without damage from the body under the action of the magnetic target separation instrument. The stones can be drawn and moved without injuring ureteral wall, and meanwhile be disposed conveniently without easy shift.

An optical coherence tomography (OCT) system comprises: an imaging catheter; a calibration phantom removably arranged at least partially surrounding the distal end of the catheter; and a processor configured to control the catheter to acquire OCT images. The phantom has known dimensions and specific optical properties which provide non-changing calibration fiducials that span the imaging range of the system. The phantom is imaged by the catheter upon first connection to the system. The processor calculates a thickness of the phantom in the OCT image, and preforms z-offset calibration by setting the position of a phantom surface in the OCT image to a known nominal value. The known nominal value is related to one or more of the known thickness of the phantom or a diameter of the catheter sheath or a nominal angle of the light beam or the imaging range of the system.

An otoscope that utilizes ambient light is disclosed. The otoscope includes a fiberoptic cable(s), as opposed to batteries, to illuminate the inspection area. The otoscope made of non-metallic and/or non-ferrous materials to permit its safe use in highly flammable oxygen or magnetic environments. The otoscope includes a handle, a head coupled to the handle, and a specula coupled to the head. An eye piece coupled to the head opposite the specula. A reflective lens is positioned within the head. A fiber optic cable is positioned within the handle. The handle includes a first end positioned opposite a second end. The head is coupled to the first end. The fiber optic cable provides light to the reflective lens. The fiber optic cable extends from the front end to the second end. The reflective lens is oriented to reflect light to the specula.

A device that can be used for in vivo fluorescence measurements by endoscopy or laparoscopy, including: an excitation light source illuminating an object, for example biological tissue, and inducing emission of emission light by the examined object, the emission light is, for example, a fluorescence light; a telemetry sensor emitting a telemetry light beam towards the object; a projector element to project the excitation beam and the telemetry beam directly on the object. The telemetry sensor can estimate a distance between the projector element and the object, which distance makes it possible to modulate intensity of the excitation light emitted by the object. When the object is biological tissue, this makes it possible to comply with illumination thresholds of biological tissue and to maintain an illumination of constant intensity. The projector element can be included at the end of a laparoscope or of an endoscope.

A medical system includes an interventional instrument and a control system including one or more processors. The control system is configured to: receive a pose dataset for a point on the instrument retained in compliant movement with a cyclically moving patient anatomy for a plurality of time parameters during a cyclical anatomical motion; determine a set of pose differentials for the identified point with respect to a reference point at each time parameter; identify a periodic signal for the anatomical motion from the set of pose differentials; generate a command signal indicating an intended movement of the instrument relative to the patient anatomy; adjust the command signal to include an instruction for a cyclical instrument motion based on a phase of the anatomical motion; and cause the intended movement of the instrument relative to the patient anatomy based on the adjusted command signal to compensate for the anatomical motion.

The disclosed technology is directed to a fixing unit of a light guide member. The fixing unit is attaching the light guide member to a protective member that protects outer circumference of the light guide member that guides primary light and a holding member. The fixing unit comprises a defining member forming a spatial region in which the protective member and the holding member are encapsulated separately from one another in a longitudinal axis direction of the fixing unit. An adhesive that is applied in the spatial region to bond at least part of the protective member and at least part of the holding member to the defining member. The defining member includes a specific region that defines a bonding range of the adhesive in the spatial region in at least one of a longitudinal axis direction and a radial direction of the defining member.

An otoscope uses differential reflected response of optical energy at an absorption range and an adjacent wavelength range to determine the presence of water (where the wavelengths are water absorption wavelength and adjacent non-absorption excitation wavelengths). In another example of the invention, the otoscope utilizes OCT in combination with absorption and non-absorption range for bacteria and water.

An imaging probe comprises a camera or endoscope with an external detector array, in which the probe is sized and shaped for surgical placement in an eye to image the eye from an interior of the eye during treatment. The imaging probe and a treatment probe can be coupled together with a fastener or contained within a housing. The imaging probe and the treatment probe can be sized and shaped to enter the eye through an incision in the cornea and image one or more of the ciliary body band or the scleral spur. The treatment probe may comprise a treatment optical fiber or a surgical placement device to deliver an implant. A processor coupled to the detector can be configured with instructions to identify a location of one or more of the ciliary body band, the scleral spur, Schwalbe's line, or Schlemm's canal from the image.

An imaging probe comprises a camera or endoscope with an external detector array, in which the probe is sized and shaped for surgical placement in an eye to image the eye from an interior of the eye during treatment. The imaging probe and a treatment probe can be coupled together with a fastener or contained within a housing. The imaging probe and the treatment probe can be sized and shaped to enter the eye through an incision in the cornea and image one or more of the ciliary body band or the scleral spur. The treatment probe may comprise a treatment optical fiber or a surgical placement device to deliver an implant. A processor coupled to the detector can be configured with instructions to identify a location of one or more of the ciliary body band, the scleral spur, Schwalbe's line, or Schlemm's canal from the image.