The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.

The invention relates to a conversion method that is fed with a diol feedstock that comprises at least 90% by weight of diol and a carboxylic acid feedstock that comprises at least 80% by weight of carboxylic acid. The method comprising at least: An esterification step which is fed with at least the diol feedstock and at least the carboxylic acid feedstock, wherein the carboxylic acid/diol molar ratio at the inlet of the esterification step is between 2 and 6, the esterification step comprises at least one reactive distillation column that has a mixed reaction/separation zone located between two separation zones; and A water elimination step that is fed with distillate from the esterification step that comprises water and producing at least one water effluent.

The invention relates to a conversion method that is fed with a diol feedstock that comprises at least 90% by weight of diol and a carboxylic acid feedstock that comprises at least 80% by weight of carboxylic acid. The method comprising at least: An esterification step which is fed with at least the diol feedstock and at least the carboxylic acid feedstock, wherein the carboxylic acid/diol molar ratio at the inlet of the esterification step is between 2 and 6, the esterification step comprises at least one reactive distillation column that has a mixed reaction/separation zone located between two separation zones; and A water elimination step that is fed with distillate from the esterification step that comprises water and producing at least one water effluent.

The invention relates to a conversion method that is fed with a diol feedstock that comprises at least 90% by weight of diol and a carboxylic acid feedstock that comprises at least 80% by weight of carboxylic acid. The method comprising at least: An esterification step which is fed with at least the diol feedstock and at least the carboxylic acid feedstock, wherein the carboxylic acid/diol molar ratio at the inlet of the esterification step is between 2 and 6, the esterification step comprises at least one reactive distillation column that has a mixed reaction/separation zone located between two separation zones; and A water elimination step that is fed with distillate from the esterification step that comprises water and producing at least one water effluent.

The present invention relates to a biphenyl derivative and use thereof, and the biphenyl derivative has a structure represented by the formula (I) as defined in the specification. The use refers the use of the biphenyl derivative or a pharmaceutically acceptable salt or solvate thereof, or a pharmaceutical composition comprising the biphenyl derivative or a pharmaceutically acceptable salt or solvate thereof in the preparation of a medicament for the treatment and/or prevention of ischemic stroke.

The present invention relates to a biphenyl derivative and use thereof, and the biphenyl derivative has a structure represented by the formula (I) as defined in the specification. The use refers the use of the biphenyl derivative or a pharmaceutically acceptable salt or solvate thereof, or a pharmaceutical composition comprising the biphenyl derivative or a pharmaceutically acceptable salt or solvate thereof in the preparation of a medicament for the treatment and/or prevention of ischemic stroke.

The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.

The present invention relates to a biphenyl derivative and use thereof, and the biphenyl derivative has a structure represented by the formula (I) as defined in the specification. The use refers the use of the biphenyl derivative or a pharmaceutically acceptable salt or solvate thereof, or a pharmaceutical composition comprising the biphenyl derivative or a pharmaceutically acceptable salt or solvate thereof in the preparation of a medicament for the treatment and/or prevention of ischemic stroke.

The invention relates to a conversion method that is fed with a diol feedstock that comprises at least 90% by weight of diol and a carboxylic acid feedstock that comprises at least 80% by weight of carboxylic acid. The method comprising at least: An esterification step which is fed with at least the diol feedstock and at least the carboxylic acid feedstock, wherein the carboxylic acid/diol molar ratio at the inlet of the esterification step is between 2 and 6, the esterification step comprises at least one reactive distillation column that has a mixed reaction/separation zone located between two separation zones; and A water elimination step that is fed with distillate from the esterification step that comprises water and producing at least one water effluent.

The invention relates to a conversion method that is fed with a diol feedstock that comprises at least 90% by weight of diol and a carboxylic acid feedstock that comprises at least 80% by weight of carboxylic acid. The method comprising at least: An esterification step which is fed with at least the diol feedstock and at least the carboxylic acid feedstock, wherein the carboxylic acid/diol molar ratio at the inlet of the esterification step is between 2 and 6, the esterification step comprises at least one reactive distillation column that has a mixed reaction/separation zone located between two separation zones; and A water elimination step that is fed with distillate from the esterification step that comprises water and producing at least one water effluent.