When a healthy and balanced diet is not achieved, nutritional supplements are used to help deal with the resulting health issues and enhance the body's performance. Two compounds of interest in this research, ketone bodies and β-Hydroxy β-Methylbutyrate (HMB) have been used for dealing with the side effects of various health conditions including muscle mass loss and insufficient food intake. Although these molecules have been used extensively as supplements, no supplement was found which combined the properties of both ketone bodies and HMB. This project was conceived to create a novel category of molecules that combine the properties of both ketone bodies and HMB that can be used as supplements for treating a wide range of health-related issues. Acetoacetate and isopentyldiol were used as the sources of ketone bodies and HMB, respectively. Six novel compounds were synthesized using transesterification of acetoacetate and isopentyldiol. Some of the developed reaction procedures were versatile as they could be performed under a variety of parameters such as solventless, catalyst-free, and mild conditions. Immobilized enzymes and chemicals were used to generate new compounds under greener parameters. The compounds that were isolated were characterized using GCMS, H NMR, and FTIR instrumentation. In summary, the goal of this research project was to design and synthesize novel ketone body analogs.

One aspect of the present invention relates to compounds, compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyloidosis-associated pathological condition and can be monitored by using a PET or SPECT camera.

When a healthy and balanced diet is not achieved, nutritional supplements are used to help deal with the resulting health issues and enhance the body's performance. The present invention relates to a novel category of molecules that combine the properties of both ketone bodies and β-Hydroxy β-Methylbutyrate (HMB) that can be used as supplements for treating a wide range of health-related issues. Acetoacetate and β-Hydroxybutrate along with isopentyldiol were used as the sources of ketone bodies and HMB, respectively. The present invention provides a method of synthesis for a new group of compounds that incorporate the properties found in acetoacetate and 3-hydroxybutyrate molecules with that of β-hydroxy β-methylbutyrate.

When a healthy and balanced diet is not achieved, nutritional supplements are used to help deal with the resulting health issues and enhance the body's performance. The present invention relates to a novel category of molecules that combine the properties of both ketone bodies and β-Hydroxy β-Methylbutyrate (HMB) that can be used as supplements for treating a wide range of health-related issues. Acetoacetate and β-Hydroxybutrate along with isopentyldiol were used as the sources of ketone bodies and HMB, respectively. The present invention provides a method of synthesis for a new group of compounds that incorporate the properties found in acetoacetate and 3-hydroxybutyrate molecules with that of β-hydroxy β-methylbutyrate.

The present invention addresses the problem of providing a novel compound which readily dissolves in liquid epoxy resins and which can be a hardener for epoxy resins to give cured objects excellent in terms of heat resistance and chemical resistance. Provided as a means for solving the problem is a polyacyloxymethyl-4,4′-acyloxybiphenyl compound represented by formula (1).

The present invention addresses the problem of providing a novel compound which readily dissolves in liquid epoxy resins and which can be a hardener for epoxy resins to give cured objects excellent in terms of heat resistance and chemical resistance. Provided as a means for solving the problem is a polyacyloxymethyl-4,4′-acyloxybiphenyl compound represented by formula (1).

Novel CUR- and CUR-BF.sub.2 compounds as well as novel bis and mono-NSAID/CUR-BF.sub.2 and NSAID/CUR hybrids exhibiting anti-tumor properties are presented. CUR compounds bearing fluorinated moieties with selective fluorine introduction into the -carbonyl moiety as well as CUR-BF.sub.2 adducts and CURs with diverse substitution patterns in the phenyl rings including fluorinated substituents (SCF.sub.3, OCF.sub.3, and F) and/or bulky activating groups (OMe, OAc, and OBz) are presented. Fluorinated aryl-pyrazoles and isoxazoles as well as novel CUR and CUR-BF.sub.2 compounds with monocyclic aromatic and bicyclic-heteroaromatic lateral rings, bearing fluorine(s), OCF.sub.3, CF.sub.3, and SCF.sub.3 groups, and their alpha-carbonyl-fluorinated analogs, as well as their pyrazole and isoxazole derivatives are presented. The CUR-pyrazoles embody analogs that are fluorinated at the phenyl-pyrazole moiety. The hybrids, compounds, and their derivatives exhibited exceptional cytotoxic and anti-proliferative activity against several cancer cell-lines. The hybrid NSAID/CUR compounds also exhibited exceptional anti-inflammatory activity over NSAID or curcumin alone.

Novel CUR- and CUR-BF.sub.2 compounds as well as novel bis and mono-NSAID/CUR-BF.sub.2 and NSAID/CUR hybrids exhibiting anti-tumor properties are presented. CUR compounds bearing fluorinated moieties with selective fluorine introduction into the -carbonyl moiety as well as CUR-BF.sub.2 adducts and CURs with diverse substitution patterns in the phenyl rings including fluorinated substituents (SCF.sub.3, OCF.sub.3, and F) and/or bulky activating groups (OMe, OAc, and OBz) are presented. Fluorinated aryl-pyrazoles and isoxazoles as well as novel CUR and CUR-BF.sub.2 compounds with monocyclic aromatic and bicyclic-heteroaromatic lateral rings, bearing fluorine(s), OCF.sub.3, CF.sub.3, and SCF.sub.3 groups, and their alpha-carbonyl-fluorinated analogs, as well as their pyrazole and isoxazole derivatives are presented. The CUR-pyrazoles embody analogs that are fluorinated at the phenyl-pyrazole moiety. The hybrids, compounds, and their derivatives exhibited exceptional cytotoxic and anti-proliferative activity against several cancer cell-lines. The hybrid NSAID/CUR compounds also exhibited exceptional anti-inflammatory activity over NSAID or curcumin alone.

The invention provides compounds for use in inhibiting a microbial alternative oxidase (AOX) and/or cytochrome bc.sub.1 complex. The invention extends to the use of such inhibitors in agrochemicals and in pharmaceuticals, for treating microbial infections, including fungal infections.

The invention provides compounds for use in inhibiting a microbial alternative oxidase (AOX) and/or cytochrome bc.sub.1 complex. The invention extends to the use of such inhibitors in agrochemicals and in pharmaceuticals, for treating microbial infections, including fungal infections.