This disclosure provides methods for the chemical modification of triglycerides that are highly enriched in specific fatty acids and subsequent use thereof for producing functionally versatile polymers.

The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

A branched estolide compound of the formula: ##STR00001##
wherein x and y are equal to 1 or greater;
wherein x+y=14;
wherein n is 0, 1, or greater than 1;
wherein R is H or wherein R=C1 to C18 straight alcohols or C4 to C12 branched alcohols;
wherein R.sub.1 is a residual fragment of octanoic, decanoic, lauric, coconut, myristic, palmitic, stearic, oleic, iso-stearic or iso-oleic acids.

A branched estolide compound of the formula: ##STR00001##
wherein x and y are equal to 1 or greater;
wherein x+y=14;
wherein n is 0, 1, or greater than 1;
wherein R is H or wherein R=C1 to C18 straight alcohols or C4 to C12 branched alcohols;
wherein R.sub.1 is a residual fragment of octanoic, decanoic, lauric, coconut, myristic, palmitic, stearic, oleic, iso-stearic or iso-oleic acids.

This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate.

This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate.

A compound, represented by Formula (1): wherein, in Formula (1), R represents a linear, branched, or cyclic alkyl group having 1 to 4 carbon atoms.

##STR00001##

A compound, represented by Formula (1): wherein, in Formula (1), R represents a linear, branched, or cyclic alkyl group having 1 to 4 carbon atoms.

##STR00001##

The present disclosure provides processes for making pleuromutilins.