Process for preparing (1R,2S)-2,6-dimethyl-1-indanamine by dynamic-kinetic stereoisomer cleavage

There is described a process for preparing virtually enantiopure (1R,2S)-2,6-dimethyl-1-indanamine, characterized by reaction of a mixture of the four stereoisomers of 2,6-dimethyl-1-indanamine with an acylation or carboxylation agent in the presence of a protein having the activity of a lipase and carried out under dynamic-kinetic stereoisomer cleavage.

Process for preparing (1R,2S)-2,6-dimethyl-1-indanamine by dynamic-kinetic stereoisomer cleavage

There is described a process for preparing virtually enantiopure (1R,2S)-2,6-dimethyl-1-indanamine, characterized by reaction of a mixture of the four stereoisomers of 2,6-dimethyl-1-indanamine with an acylation or carboxylation agent in the presence of a protein having the activity of a lipase and carried out under dynamic-kinetic stereoisomer cleavage.

Provided is an amine separation method that includes separating an amine through chromatography using a stationary phase including a ligand having a crown ether-like cyclic structure and being supported on a carrier; and a mobile phase containing a salt of a cation and an acid anion at a concentration of 0.2 mM or more and 50.0 mM or less and containing a solvent having a water content of 50 vol. % or less.

Provided is an amine separation method that includes separating an amine through chromatography using a stationary phase including a ligand having a crown ether-like cyclic structure and being supported on a carrier; and a mobile phase containing a salt of a cation and an acid anion at a concentration of 0.2 mM or more and 50.0 mM or less and containing a solvent having a water content of 50 vol. % or less.