The present disclosure provides adamantyl compounds having one or more amine groups and one or more nitrate groups. The aminoadamantyl nitrate compounds can be used to treat disorders of the central nervous system, including neurodegenerative and non-neurodegenerative diseases.

A manufacturing method of an amine compound including obtaining a reaction solution containing an aldehyde compound by reacting a compound represented by Formula (a1) or (a2) with hydrogen and carbon monoxide in the presence of a metal compound of groups 8 to 10 and a phosphorus compound, neutralizing the reaction, purifying an aldehyde compound by distilling the neutralized reaction solution, and reacting the aldehyde compound with ammonia and with hydrogen in the presence of a catalyst to obtain an amine compound, wherein the phosphorus compound is represented by the Formula (R.sup.1O).sub.3P, and the base compound is at least one selected from carbonate and hydrogen carbonate of metals of group I and carbonate and hydrogen carbonate of metals of group II,

##STR00001##

and wherein the neutralizing the reaction solution is performed within a temperature range of 40 C. to 50 C.

A manufacturing method of an amine compound including obtaining a reaction solution containing an aldehyde compound by reacting a compound represented by Formula (a1) or (a2) with hydrogen and carbon monoxide in the presence of a metal compound of groups 8 to 10 and a phosphorus compound, neutralizing the reaction, purifying an aldehyde compound by distilling the neutralized reaction solution, and reacting the aldehyde compound with ammonia and with hydrogen in the presence of a catalyst to obtain an amine compound, wherein the phosphorus compound is represented by the Formula (R.sup.1O).sub.3P, and the base compound is at least one selected from carbonate and hydrogen carbonate of metals of group I and carbonate and hydrogen carbonate of metals of group II,

##STR00001##

and wherein the neutralizing the reaction solution is performed within a temperature range of 40 C. to 50 C.

A manufacturing method of an isocyanate compound including obtaining a reaction solution containing an aldehyde compound by reacting a compound represented by Formula (a1) or (a2) with hydrogen and carbon monoxide in the presence of a metal compound of groups 8 to 10 and a phosphorus compound, neutralizing the reaction solution, purifying an aldehyde compound by distilling the neutralized reaction solution, reacting the aldehyde compound with ammonia and with hydrogen in the presence of a catalyst to obtain an amine compound; and reacting the amine compound with a carbonylating agent to obtain an isocyanate compound, wherein the phosphorus compound is represented by the Formula (R.sup.1O).sub.3P, and the base compound is at least one selected from carbonate and hydrogen carbonate of metals of group I and carbonate and hydrogen carbonate of metals of group II,

##STR00001##

wherein the neutralizing the reaction solution is performed within a temperature range of 40 C. to 50 C.

A manufacturing method of an isocyanate compound including obtaining a reaction solution containing an aldehyde compound by reacting a compound represented by Formula (a1) or (a2) with hydrogen and carbon monoxide in the presence of a metal compound of groups 8 to 10 and a phosphorus compound, neutralizing the reaction solution, purifying an aldehyde compound by distilling the neutralized reaction solution, reacting the aldehyde compound with ammonia and with hydrogen in the presence of a catalyst to obtain an amine compound; and reacting the amine compound with a carbonylating agent to obtain an isocyanate compound, wherein the phosphorus compound is represented by the Formula (R.sup.1O).sub.3P, and the base compound is at least one selected from carbonate and hydrogen carbonate of metals of group I and carbonate and hydrogen carbonate of metals of group II,

##STR00001##

wherein the neutralizing the reaction solution is performed within a temperature range of 40 C. to 50 C.

Disclosed herein are embodiments of methods for preparing aminated or alkylaminated CNTs wherein the aminated or alkylaminated CNTs are obtained in a reaction by reacting the CNTs with an aminating or alkylaminating reagent in a non-hazardous solvent or a non-hazardous solvent-deionized water mixture. The CNTs may be single-walled, double-walled or multi-walled CNTs. The disclosed processes for amination and alkylamination do not require treatment with concentrated acid, and with the use of solvent, the CNTs and aminating compound or alkylaminating compound are mixed thoroughly throughout the reaction.

Disclosed herein are embodiments of methods for preparing aminated or alkylaminated CNTs wherein the aminated or alkylaminated CNTs are obtained in a reaction by reacting the CNTs with an aminating or alkylaminating reagent in a non-hazardous solvent or a non-hazardous solvent-deionized water mixture. The CNTs may be single-walled, double-walled or multi-walled CNTs. The disclosed processes for amination and alkylamination do not require treatment with concentrated acid, and with the use of solvent, the CNTs and aminating compound or alkylaminating compound are mixed thoroughly throughout the reaction.

Disclosed herein are compounds of the general Formula (I), and methods of synthesizing substituted bicyclo[1.1.1 jpentanes. The synthetic methods described herein use a [1.1.1]propellane, a Group VIII transition metal compound, a hydride source and a reagent that can contribute a substituent to form a substituted bicyclo[1.1.1]pentane, such as a compound of the general Formula (I).

Disclosed herein are compounds of the general Formula (I), and methods of synthesizing substituted bicyclo[1.1.1 jpentanes. The synthetic methods described herein use a [1.1.1]propellane, a Group VIII transition metal compound, a hydride source and a reagent that can contribute a substituent to form a substituted bicyclo[1.1.1]pentane, such as a compound of the general Formula (I).

The present invention relates to a compound of formula (I), to its use in electronic devices, to methods for producing said compound, and to electronic devices containing the compound.

##STR00001##