The present disclosure relates to methods and intermediates for the synthesis of certain compounds that inhibit MCL1, for use in the treatment of cancers.

The present disclosure relates to methods and intermediates for the synthesis of certain compounds that inhibit MCL1, for use in the treatment of cancers.

The present invention relates to new inhibitors of Notch signalling pathway and its use in the treatment and/or prevention of cancers.

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The present invention relates to new inhibitors of Notch signalling pathway and its use in the treatment and/or prevention of cancers.

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Corrosion inhibitor compositions and methods for inhibiting corrosion on a metal surface exposed to a hydrocarbon fluid are provided. The corrosion inhibition compositions can include a corrosion inhibitor, such as 3-dimethylamino benzoic acid, 4-dimethylamino benzoic acid, or 2,5-dihydroxyterephthalic acid. The corrosion inhibitor composition can further comprise dimethyl sulfoxide, and heavy aromatic naphtha. The corrosion inhibitor composition can be phosphate-free and can inhibit naphthenic acid corrosion. In the methods, a corrosion inhibitor composition is added to the hydrocarbon fluid exposed to the metal surface to prevent or inhibit corrosion on the metal surface, including naphthenic acid corrosion.

Crystalline molecular framework:small molecule compounds. The molecular framework is formed from guanidinium cations and organosulfonate anions and the guanidinium cations and organosulfonate anions are associated via one or more hydrogen bond. The small molecule(s) is/are encapsulated by the molecular framework. Methods for making crystalline molecular framework:small molecule compounds may include combining guanidinium cations, organosulfonate anions, and small molecules in a single step. The crystalline molecular framework:small molecule compounds can be used to determine the structure of the small molecule(s).

Crystalline molecular framework:small molecule compounds. The molecular framework is formed from guanidinium cations and organosulfonate anions and the guanidinium cations and organosulfonate anions are associated via one or more hydrogen bond. The small molecule(s) is/are encapsulated by the molecular framework. Methods for making crystalline molecular framework:small molecule compounds may include combining guanidinium cations, organosulfonate anions, and small molecules in a single step. The crystalline molecular framework:small molecule compounds can be used to determine the structure of the small molecule(s).

The present invention primarily relates to a process for producing certain substituted 2-allylanilines of the hereinbelow-defined formula (I) and their use in a process for producing substituted 4-aminoindane derivatives of the hereinbelow-defined formula (V). The present invention further relates to a process for producing fungicidal indanyl carboxamides. In particular, the present invention relates to a process for producing 2-(difluoromethyl)-N-(1,1-dimethyl-3-propyl-2,3-dihydro-1H-inden-4-yl)nicotinamide and/or 3-(difluoromethyl)-N-[(R)-2,3-dihydro-1,1,3-trimethyl-1H-inden-4-yl]-1-methylpyrazole-4-carboxamide.

The present invention primarily relates to a process for producing certain substituted 2-allylanilines of the hereinbelow-defined formula (I) and their use in a process for producing substituted 4-aminoindane derivatives of the hereinbelow-defined formula (V). The present invention further relates to a process for producing fungicidal indanyl carboxamides. In particular, the present invention relates to a process for producing 2-(difluoromethyl)-N-(1,1-dimethyl-3-propyl-2,3-dihydro-1H-inden-4-yl)nicotinamide and/or 3-(difluoromethyl)-N-[(R)-2,3-dihydro-1,1,3-trimethyl-1H-inden-4-yl]-1-methylpyrazole-4-carboxamide.

A process for preparing a nitrated compound, including the step of reacting a compound (A) including at least one substituted or unsubstituted aromatic or heteroaromatic ring, wherein the heteroaromatic ring includes at least one heteroatom selected from the group consisting of oxygen, sulfur, phosphor, selenium and nitrogen, with a compound of formula (I)

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wherein Y is selected from the group consisting of hydrogen and nitro.