The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.

A method for making a di(aminoaryl)fluorene compound that includes the steps of: (a) reacting a fluorenone compound according structure (I):

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with excess aminobenzene according to structure (II):

##STR00002##

wherein: each R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.12, and R.sup.13 is independently a group that is inert in the polymerization of epoxy compounds, and R.sup.11 is H or (C.sub.1-C.sub.6)alkyl, in the presence of an acid catalyst, in a liquid medium comprising an aromatic or substituted aromatic solvent having a boiling point of greater than or equal to 150° C. and from which the di(aminoaryl)fluorene compound is crystallizable, to form a crude product mixture comprising the di(aminoaryl)fluorene compound, (b) crystallizing di(aminoaryl)fluorene compound in the product mixture, and (c) separating the product mixture into crystallized di(aminoaryl)fluorene compound and a filtrate.

A method for making a di(aminoaryl)fluorene compound that includes the steps of: (a) reacting a fluorenone compound according structure (I):

##STR00001##

with excess aminobenzene according to structure (II):

##STR00002##

wherein: each R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.12, and R.sup.13 is independently a group that is inert in the polymerization of epoxy compounds, and R.sup.11 is H or (C.sub.1-C.sub.6)alkyl, in the presence of an acid catalyst, in a liquid medium comprising an aromatic or substituted aromatic solvent having a boiling point of greater than or equal to 150° C. and from which the di(aminoaryl)fluorene compound is crystallizable, to form a crude product mixture comprising the di(aminoaryl)fluorene compound, (b) crystallizing di(aminoaryl)fluorene compound in the product mixture, and (c) separating the product mixture into crystallized di(aminoaryl)fluorene compound and a filtrate.

The invention discloses a method for the preparation of fluoro alkylated compounds by homogeneous Ni catalyzed fluoro alkylation with fluoro alkyl halides in the presence of a base.

The invention discloses a method for the preparation of fluoro alkylated compounds by homogeneous Ni catalyzed fluoro alkylation with fluoro alkyl halides in the presence of a base.

An isoxazoline-substituted benzamide compound, and the salt thereof. For example, a compound having the following formula:

##STR00001##

and pesticides characterized by containing the compound as an active ingredient.

An isoxazoline-substituted benzamide compound, and the salt thereof. For example, a compound having the following formula:

##STR00001##

and pesticides characterized by containing the compound as an active ingredient.

Provided are a polymer having a constituent component represented by formula (I) below, a method for producing the polymer, a diamine compound suitable as a raw material for the polymer, a gas separation membrane haying a gas separation layer including the polymer, and a gas separation module and a gas separation apparatus that have the gas separation membrane. ##STR00001## In the formula (I), R.sup.A, R.sup.B, and R.sup.C represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or a halogen atom. Herein, at least one of R.sup.A, R.sup.B, or R.sup.C represents an alkyl group having 1 to 4 carbon atoms or a halogen atom. The alkyl group having 1 to 4 carbon atoms is not trifluoromethyl and ** represents linking sites.

Provided are a polymer having a constituent component represented by formula (I) below, a method for producing the polymer, a diamine compound suitable as a raw material for the polymer, a gas separation membrane haying a gas separation layer including the polymer, and a gas separation module and a gas separation apparatus that have the gas separation membrane. ##STR00001## In the formula (I), R.sup.A, R.sup.B, and R.sup.C represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or a halogen atom. Herein, at least one of R.sup.A, R.sup.B, or R.sup.C represents an alkyl group having 1 to 4 carbon atoms or a halogen atom. The alkyl group having 1 to 4 carbon atoms is not trifluoromethyl and ** represents linking sites.

The present invention generally relates to processes for the catalytic hydrogenation of halonitroaromatics. In particular, the present invention includes processes for the catalytic hydrogenation of halonitroaromatics such as 2,5-dicloronitrobenzene to 2,5-dichloroaniline over a platinum-containing catalyst. The present invention also relates to processes for producing 3,6-dichloro-2-methoxybenzoic acid.