Patent classifications
C07C215/24
NOVEL AMINO ACID DERIVATIVES
- Haruaki KURASAKI ,
- Naoki OKADA ,
- Katsuma MATSUI ,
- Masatoshi TAKUWA ,
- Kyosuke UEDA ,
- Masatoshi MATSUMOTO ,
- Shunichi NAKANO ,
- Yoshihide MIZUKOSHI ,
- Atsushi YOSHIZAWA ,
- Akihiro KUROO ,
- Ayumu MATSUDA ,
- Motoki MURAI ,
- Masahiko KINEBUCHI ,
- Tomoko ASHIZAWA ,
- Kentarou FUKUMOTO ,
- Yutaka KOBAYASHI ,
- Kouki MORIMOTO ,
- Masami YAMADA ,
- Douglas Robert CARY ,
- Makoto JITSUOKA ,
- Kotaro TOKUMOTO ,
- Keiichi MASUYA
A novel amino acid derivative is provided, wherein the amino acid derivative is expected to improve binding affinity of polypeptides comprising the derivative the rein.
METHODS FOR THE SYNTHESIS OF SPHINGOMYELINS AND DIHYDROSPHINGOMYELINS
The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.
Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.
Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.
Cationic lipid compounds
The compounds disclosed herein compound of Formula (I), substructures thereof, and pharmaceutically acceptable salts thereof. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins. ##STR00001##
Cationic lipid compounds
The compounds disclosed herein compound of Formula (I), substructures thereof, and pharmaceutically acceptable salts thereof. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins. ##STR00001##
BIS(PHOSPHINE)-CARBODICARBENE CATALYST COMPLEXES AND METHODS OF USING THE SAME
An organometallic complex of a tridentate bis(phosphine)-carbodicarbene ligand and a transition metal, is described. In some embodiments the ligand has the structure of Formula (I): The complexes are useful in methods of making an allylic amine carried out by reacting a 1,3-diene with a substituted amine in the presence of such an organometallic complex to produce by intermolecular hydroamination the allylic amine.
##STR00001##
BIS(PHOSPHINE)-CARBODICARBENE CATALYST COMPLEXES AND METHODS OF USING THE SAME
An organometallic complex of a tridentate bis(phosphine)-carbodicarbene ligand and a transition metal, is described. In some embodiments the ligand has the structure of Formula (I): The complexes are useful in methods of making an allylic amine carried out by reacting a 1,3-diene with a substituted amine in the presence of such an organometallic complex to produce by intermolecular hydroamination the allylic amine.
##STR00001##
Cationic lipids and transfection methods
The present invention relates in part to novel cationic lipids and their use, e.g., in delivering nucleic acids to cells.
Cationic lipids and transfection methods
The present invention relates in part to novel cationic lipids and their use, e.g., in delivering nucleic acids to cells.