Patent classifications
C07C217/28
Dendrimer and formulations thereof
The present invention relates to a novel dendrimer. The present invention also relates to formulations comprising the dendrimer with improved characteristics. For instance, the present invention relates to formulations comprising pesticides such as 2-(2,4-dichlorophenoxy)acetic acid with improved characteristics such as reduced crystallisation, compatibility with hard water and an extended shelf life at low temperatures.
Dendrimer and formulations thereof
The present invention relates to a novel dendrimer. The present invention also relates to formulations comprising the dendrimer with improved characteristics. For instance, the present invention relates to formulations comprising pesticides such as 2-(2,4-dichlorophenoxy)acetic acid with improved characteristics such as reduced crystallisation, compatibility with hard water and an extended shelf life at low temperatures.
COMPOSITIONS AND METHODS FOR TREATMENT OF CENTRAL NERVOUS SYSTEM TUMORS
Compounds, pharmaceutical compositions, and methods for treating cancer, in particular brain cancer, are provided, including amphiphilic fatty acid/alcohol ethers (AlPs) comprising endocannabinoid and FABP motifs covalently linked to a beta-adrenoreceptor antagonist motif in one molecule. The invention includes methods for inhibiting growth of brain cancer cells by contacting the compound(s) with brain cancer cells. The invention provides a method for treating both brain cancer and brain cancer metastases, and for suppression of regrowth of brain cancer cells after radiation, surgical treatment, or chemotherapy of brain cancer. The invention also comprises an optimized chemical synthesis of the AIP compounds and methods of using the compounds, alone or in combination with another agent, for suppressing the growth of brain cancer cells, and enhancing survival of normal CNS cells, or improving recuperation from radiation, surgical or chemotherapy.
COMPOSITIONS AND METHODS FOR TREATMENT OF CENTRAL NERVOUS SYSTEM TUMORS
Compounds, pharmaceutical compositions, and methods for treating cancer, in particular brain cancer, are provided, including amphiphilic fatty acid/alcohol ethers (AlPs) comprising endocannabinoid and FABP motifs covalently linked to a beta-adrenoreceptor antagonist motif in one molecule. The invention includes methods for inhibiting growth of brain cancer cells by contacting the compound(s) with brain cancer cells. The invention provides a method for treating both brain cancer and brain cancer metastases, and for suppression of regrowth of brain cancer cells after radiation, surgical treatment, or chemotherapy of brain cancer. The invention also comprises an optimized chemical synthesis of the AIP compounds and methods of using the compounds, alone or in combination with another agent, for suppressing the growth of brain cancer cells, and enhancing survival of normal CNS cells, or improving recuperation from radiation, surgical or chemotherapy.
SURFACTANTS HAVING NON-CONVENTIONAL HYDROPHOBES
The present invention is directed to surfactants with small hydrophobes, which are of non-conventional hydrophobe size. The surfactants of the present invention utilize a small hydrophobic moiety with a polvalkoxylate chain comprising PO, BO and/or EO groups, with optional ionic groups, such as anionic, cationic and zwitterionic, to achieve the desired hydrophilic-lipophilic balance (HLB). The present invention is further directed to formulations comprising the surfactants of the invention, and methods of using the surfactants of the invention, including in enhanced oil recovery applications.
SURFACTANTS HAVING NON-CONVENTIONAL HYDROPHOBES
The present invention is directed to surfactants with small hydrophobes, which are of non-conventional hydrophobe size. The surfactants of the present invention utilize a small hydrophobic moiety with a polvalkoxylate chain comprising PO, BO and/or EO groups, with optional ionic groups, such as anionic, cationic and zwitterionic, to achieve the desired hydrophilic-lipophilic balance (HLB). The present invention is further directed to formulations comprising the surfactants of the invention, and methods of using the surfactants of the invention, including in enhanced oil recovery applications.
Biological buffers with wide buffering ranges
Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.
Biological buffers with wide buffering ranges
Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.
SILANE COMPOUND CONTAINING PERFLUOROPOLYETHER GROUP, PREPARATION METHOD THEREFOR, SURFACE TREATMENT AGENT AND PRODUCT THEREOF
The present invention relates to a perfluoropolyether group-containing silane compound represented by formula (1): RfX.sup.1X.sup.2NQ.sub.kT.sub.2-k (1), and a method for preparing the same. The present invention also relates to a perfluoropolyether group-containing silane compound represented by formula (2),
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and a method for preparing the same. The present invention also relates to a perfluoropolyether group-containing silane compound represented by formula (3),
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and a method for preparing the same. The perfluoropolyether group-containing silane compound of the present invention can be used for a surface treatment agent so that the substrates such as glass etc processed by the surface treatment agent are excellent in anti-fouling, anti-fingerprint, scrape resistant and abrasion resistant performances. Moreover, the preparation method of each of the compounds of the present invention is simple in process, easy to operate and implement.
PERFLUOROPOLYETHER COMPOUND CONTAINING CARBOXYL GROUP
The present invention relates to a carboxyl group containing perfluoropolyether compound of formula (I): RfX.sup.1X.sup.2(I). In the formula RfX.sup.1X.sup.2(I), Rf represents F(CF.sub.2).sub.m(OC.sub.4F.sub.8).sub.p(OC.sub.3F.sub.6).sub.q(OC.sub.2F.sub.4).sub.r(OCF.sub.2).sub.sOC(Z)F(CF.sub.2).sub.n, wherein p, q, r and s are each independently an integer of 0 or more and 200 or less, and the sum of p, q, r and s is at least 1; in the formula, the occurrence order and number of the respective repeating units in parentheses with the subscript p, q, r or s are arbitrary in the formula; m and n are each independently an integer of 0 or more and 30 or less, Z is F or CF.sub.3; X.sup.1 represents a divalent organic group; and X.sup.2 represents a COOH group.