The present invention relates to the field of fuel additives for fuel compositions and more particularly to a composition that can be used as a friction modifier, and its preparation process. More particularly, the present invention concerns a composition comprising at least one fatty acid amide of diethanolamine (DEA) and at least one fatty acid ester and/or amide of DEA oligomer, and it preparation process.

Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.

Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.

A bis(perfluoroether carboxylic acid alkyl)amino ester represented by the general formula: {C.sub.nF.sub.2n+1O[CF(CF.sub.3)CF.sub.2O].sub.aCF(CF.sub.3)COO(CH.sub.2).sub.b}.sub.2NR, wherein R is a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, an aryl group, or an aralkyl group; preferably an alkyl group having 1 to 6 carbon atoms or an aryl group; n is an integer of 1 to 3; a is an integer of 0 to 20, preferably an integer of 1 to 6; and b is an integer of 1 to 12, preferably an integer of 1 to 4. The bis(perfluoroether carboxylic acid alkyl)amino ester having an amino group at the end of the ester group is produced by reacting a perfluoroether carboxylic acid fluoride compound of the formula: C.sub.nF.sub.2n+1O[CF(CF.sub.3)CF.sub.2O].sub.aCF(CF.sub.3)COF and a bis(hydroxyalkyl)amine compound of the formula: HO(CH.sub.2).sub.bNR(CH.sub.2).sub.bOH at a molar ratio of 2:1 in the presence of an alkali metal fluoride.

A bis(perfluoroether carboxylic acid alkyl)amino ester represented by the general formula: {C.sub.nF.sub.2n+1O[CF(CF.sub.3)CF.sub.2O].sub.aCF(CF.sub.3)COO(CH.sub.2).sub.b}.sub.2NR, wherein R is a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, an aryl group, or an aralkyl group; preferably an alkyl group having 1 to 6 carbon atoms or an aryl group; n is an integer of 1 to 3; a is an integer of 0 to 20, preferably an integer of 1 to 6; and b is an integer of 1 to 12, preferably an integer of 1 to 4. The bis(perfluoroether carboxylic acid alkyl)amino ester having an amino group at the end of the ester group is produced by reacting a perfluoroether carboxylic acid fluoride compound of the formula: C.sub.nF.sub.2n+1O[CF(CF.sub.3)CF.sub.2O].sub.aCF(CF.sub.3)COF and a bis(hydroxyalkyl)amine compound of the formula: HO(CH.sub.2).sub.bNR(CH.sub.2).sub.bOH at a molar ratio of 2:1 in the presence of an alkali metal fluoride.

The present invention relates to compounds characterized by having a structure according to the following Formula I:

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or a pharmaceutically acceptable salt thereof. Compounds of the present invention are useful for the treatment or prevention of HIV.

Disclosed are cationic lipids which are compounds of Formula I. Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

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The present invention relates to a process for producing an esterquat by a transesterification reaction of a fatty acid oil or a mixture comprising one or more fatty acid oils and one or more fatty acids with a tertiary hydroxy amine and then a quaternization reaction. Esterquats obtained by the method of the invention show beneficial properties in particular when used as active component in fabric softener materials.

The present invention relates to a process for producing an esterquat by a transesterification reaction of a fatty acid oil or a mixture comprising one or more fatty acid oils and one or more fatty acids with a tertiary hydroxy amine and then a quaternization reaction. Esterquats obtained by the method of the invention show beneficial properties in particular when used as active component in fabric softener materials.

A method for treating a p62-mediated disease (e.g., multiple myeloma) in a subject, the method comprising administering to the subject a therapeutically effective amount of at least one p62-ZZ inhibitor compound.