The present invention relates to a process for the in situ preparation of mixtures of chelating agents by catalyzed reactions of diethanolamine with maleic acid and then with 2-halocarboxylic acid, mixtures obtainable using said process and mixtures of chelating agents. In addition, the invention relates to methods where such mixtures are used.

The present invention relates to a process for the in situ preparation of mixtures of chelating agents by catalyzed reactions of diethanolamine with maleic acid and then with 2-halocarboxylic acid, mixtures obtainable using said process and mixtures of chelating agents. In addition, the invention relates to methods where such mixtures are used.

A method for preparing a lisinopril intermediate is provided. The method includes: treating (R)-hydroxy-4-phenylbutyrate with sulfonyl chloride in an organic solvent in the presence of a base to obtain a solution of sulfonate; reacting the obtained solution with a salt of trifluoroacetyl lysine; and obtaining a N.sup.2-[1-(S)-alkoxycarbonyl-3-phenylpropyl]-N.sup.6-trifluoroacetyl-L-lysine by separating after the reaction is completed. The method provided has a shorter synthesis route, is easy to operate, has a low cost, and is suitable for industrial production.

A method for preparing a lisinopril intermediate is provided. The method includes: treating (R)-hydroxy-4-phenylbutyrate with sulfonyl chloride in an organic solvent in the presence of a base to obtain a solution of sulfonate; reacting the obtained solution with a salt of trifluoroacetyl lysine; and obtaining a N.sup.2-[1-(S)-alkoxycarbonyl-3-phenylpropyl]-N.sup.6-trifluoroacetyl-L-lysine by separating after the reaction is completed. The method provided has a shorter synthesis route, is easy to operate, has a low cost, and is suitable for industrial production.

A method for preparing a lisinopril intermediate is provided. The method includes: treating (R)-hydroxy-4-phenylbutyrate with sulfonyl chloride in an organic solvent in the presence of a base to obtain a solution of sulfonate; reacting the obtained solution with a salt of trifluoroacetyl lysine; and obtaining a N.sup.2-[1-(S)-alkoxycarbonyl-3-phenylpropyl]-N.sup.6-trifluoroacetyl-L-lysine by separating after the reaction is completed. The method provided has a shorter synthesis route, is easy to operate, has a low cost, and is suitable for industrial production.

Methods of synthesizing fluoroquinolones such as ciprofloxacin are provided. The methods utilize affordable materials, reduce the number of synthesis steps and provide high yields.

Methods of synthesizing fluoroquinolones such as ciprofloxacin are provided. The methods utilize affordable materials, reduce the number of synthesis steps and provide high yields.

A process for synthesizing a product of formula Br(CH.sub.2).sub.nR by hydrobromination, by reacting: a reagent of formula (I) R1-CHCHR2 in which R1 and R2, identical or different, are chosen from H or an alkyl radical comprising 1 to 30 carbon atoms, which is saturated or unsaturated, linear or branched, functionalized or non-functionalized, with a molar excess of HBr relative to the reagent of formula (I), in the presence of a radical initiator, and optionally in the presence of at least one solvent, said process including a step A of mixing at least reagent I and the HBr, each of the latter arriving in the form of a flow of liquid into a mixing device dA.

A process for synthesizing a product of formula Br(CH.sub.2).sub.nR by hydrobromination, by reacting: a reagent of formula (I) R1-CHCHR2 in which R1 and R2, identical or different, are chosen from H or an alkyl radical comprising 1 to 30 carbon atoms, which is saturated or unsaturated, linear or branched, functionalized or non-functionalized, with a molar excess of HBr relative to the reagent of formula (I), in the presence of a radical initiator, and optionally in the presence of at least one solvent, said process including a step A of mixing at least reagent I and the HBr, each of the latter arriving in the form of a flow of liquid into a mixing device dA.

A process for synthesizing a product of formula Br(CH.sub.2).sub.nR by hydrobromination, by reacting: a reagent of formula (I) R1-CHCHR2 in which R1 and R2, identical or different, are chosen from H or an alkyl radical comprising 1 to 30 carbon atoms, which is saturated or unsaturated, linear or branched, functionalized or non-functionalized, with a molar excess of HBr relative to the reagent of formula (I), in the presence of a radical initiator, and optionally in the presence of at least one solvent, said process including a step A of mixing at least reagent I and the HBr, each of the latter arriving in the form of a flow of liquid into a mixing device dA.