The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas:

##STR00001##

wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.

Provided herein are methods of altering enantiomeric excess. The methods may include irradiating an atropisomer that includes at least one chiral substituent to alter the enantiomeric excess of the atropisomer. The at least one chiral substituent may be removed following irradiation.

Provided herein are methods of altering enantiomeric excess. The methods may include irradiating an atropisomer that includes at least one chiral substituent to alter the enantiomeric excess of the atropisomer. The at least one chiral substituent may be removed following irradiation.

In various embodiments a cancer treatment method is provided based on inhibition of proline catabolism. When combined with p53 restoration therapy and/or inhibition of glutaminase, the inhibition of proline catabolism results in a synthetic lethal and synergistic anticancer response. Novel suicide inhibitors that induce the degradation of proline dehydrogenase (PRODH) are also provided. Also provided is a method of assaying PRODH to identify responders/non-responders to inhibition of proline catabolism and/or glutaminase.

In various embodiments a cancer treatment method is provided based on inhibition of proline catabolism. When combined with p53 restoration therapy and/or inhibition of glutaminase, the inhibition of proline catabolism results in a synthetic lethal and synergistic anticancer response. Novel suicide inhibitors that induce the degradation of proline dehydrogenase (PRODH) are also provided. Also provided is a method of assaying PRODH to identify responders/non-responders to inhibition of proline catabolism and/or glutaminase.

An oil-water separation apparatus is provided which can easily separate and collect oil from a liquid mixture containing water and oil at low cost. The oil-water separation apparatus includes an oil-water-separating member configured to separate a liquid mixture containing water and oil into moisture and oil, and a liquid reservoir subdivided into an upper region and a lower region by the oil-water-separating member. The oil-water separation apparatus filters the liquid mixture by gravity. The oil-water-separating member includes a base which includes a channel for the liquid mixture. The oil-water-separating member is formed in the base, and the oil-water-separating member contains a fluorine compound which has an oil-repellency-imparting group and a hydrophilicity-imparting group. A drain port for discharging the moisture is formed in the lower region of the liquid reservoir.

An oil-water separation apparatus is provided which can easily separate and collect oil from a liquid mixture containing water and oil at low cost. The oil-water separation apparatus includes an oil-water-separating member configured to separate a liquid mixture containing water and oil into moisture and oil, and a liquid reservoir subdivided into an upper region and a lower region by the oil-water-separating member. The oil-water separation apparatus filters the liquid mixture by gravity. The oil-water-separating member includes a base which includes a channel for the liquid mixture. The oil-water-separating member is formed in the base, and the oil-water-separating member contains a fluorine compound which has an oil-repellency-imparting group and a hydrophilicity-imparting group. A drain port for discharging the moisture is formed in the lower region of the liquid reservoir.

The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas:

##STR00001##

wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.

The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas:

##STR00001##

wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.

The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.