Disclosed herein are acid addition salt and salt crystals of (6aR, 9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-2-((4(6-fluoropyridin-2-yl)phenyl)methyl)-cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one, compositions comprising the same as well as methods of making and using such salts and crystals.

The purpose of the invention is to develop, as drug-candidate compounds, a group of novel compounds having the activity of inhibiting functions of Pin1. The invention provides: a compound represented by formula (I) or a salt thereof; and a Pin1 inhibitor, a pharmaceutical composition, a therapeutic or prophylactic agent for inflammatory diseases, a therapeutic or prophylactic agent for cancer, and a therapeutic or prophylactic agent for adiposity that use said compound/salt. ##STR00001##

The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.

A substituted 3-fluorobenzenepropanoate compound represented by formula (I), an optical isomer thereof, a pharmaceutically acceptable salt thereof, a solvate (such as a hydrate) thereof, a clathrate thereof, a racemate thereof, a co-crystal thereof, an isotopic label thereof, or a nitrogen oxide thereof, as well as pharmaceutical compositions and uses thereof. The compound has significantly elevated drug activity, and can effectively treat and/or prevent inflammation, pain, fever, cancer, or senile dementia.

A substituted 3-fluorobenzenepropanoate compound represented by formula (I), an optical isomer thereof, a pharmaceutically acceptable salt thereof, a solvate (such as a hydrate) thereof, a clathrate thereof, a racemate thereof, a co-crystal thereof, an isotopic label thereof, or a nitrogen oxide thereof, as well as pharmaceutical compositions and uses thereof. The compound has significantly elevated drug activity, and can effectively treat and/or prevent inflammation, pain, fever, cancer, or senile dementia.