The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula:

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Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.

The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula: [INSERT CHEMICAL STRUCTURE HERE] Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis. ##STR00001##

The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula: [INSERT CHEMICAL STRUCTURE HERE] Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis. ##STR00001##

A method for producing N-vinylformamide through a vapor-phase thermal decomposition reaction using an evaporator (10) for evaporating a raw material, a thermal decomposition reactor (20) for thermally decomposing a raw material gas generated by the evaporator (10) and a condenser (30) for condensing a thermally decomposed gas generated by the thermal decomposition reactor (20), wherein the evaporation of the raw material is started in the evaporator (10) while the temperature of a tube wall of a first connection tube (40) that connects the evaporator (10) to the thermal decomposition reactor (20) satisfies a requirement represented by formula (1): (temperature of tube wall ( C.))0.37(pressure of evaporator (mmHg))+205.

A method for producing N-vinylformamide through a vapor-phase thermal decomposition reaction using an evaporator (10) for evaporating a raw material, a thermal decomposition reactor (20) for thermally decomposing a raw material gas generated by the evaporator (10) and a condenser (30) for condensing a thermally decomposed gas generated by the thermal decomposition reactor (20), wherein the evaporation of the raw material is started in the evaporator (10) while the temperature of a tube wall of a first connection tube (40) that connects the evaporator (10) to the thermal decomposition reactor (20) satisfies a requirement represented by formula (1): (temperature of tube wall ( C.))0.37(pressure of evaporator (mmHg))+205.

A method for producing N-vinylformamide through a vapor-phase thermal decomposition reaction using an evaporator (10) for evaporating a raw material, a thermal decomposition reactor (20) for thermally decomposing a raw material gas generated by the evaporator (10) and a condenser (30) for condensing a thermally decomposed gas generated by the thermal decomposition reactor (20), wherein the evaporation of the raw material is started in the evaporator (10) while the temperature of a tube wall of a first connection tube (40) that connects the evaporator (10) to the thermal decomposition reactor (20) satisfies a requirement represented by formula (1): (temperature of tube wall ( C.))0.37(pressure of evaporator (mmHg))+205.

The present application provides a preparation method of a formamide compound, the preparation process includes: uniformly mixing raw material of methanoic acid and an amine compound selected from a primary amine or a secondary amine to prepare a homogeneous reaction system; the above homogeneous reaction system is heated to 160-230 C., allowing carbon monoxide to be decomposed from the homogeneous reaction system and participates in the reaction, and collecting the reaction product to obtain a formamide compound. The present application provides a new technology using a homogeneous method to synthesize a formamide compound, the reaction process needs no use of a catalyst, the operation process is simple and controllable, and the raw material of the amine compound has a high selectivity.

The present application provides a preparation method of a formamide compound, the preparation process includes: uniformly mixing raw material of methanoic acid and an amine compound selected from a primary amine or a secondary amine to prepare a homogeneous reaction system; the above homogeneous reaction system is heated to 160-230 C., allowing carbon monoxide to be decomposed from the homogeneous reaction system and participates in the reaction, and collecting the reaction product to obtain a formamide compound. The present application provides a new technology using a homogeneous method to synthesize a formamide compound, the reaction process needs no use of a catalyst, the operation process is simple and controllable, and the raw material of the amine compound has a high selectivity.

A method of obtaining purified DMF from a mixture comprising DMF and hydrogen chloride (HCl) involving distillation is provided.

A method of obtaining purified DMF from a mixture comprising DMF and hydrogen chloride (HCl) involving distillation is provided.