Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

Disclosed herein are novel iodonium analogs having anticancer and anti-inflammatory activity.

Disclosed herein are novel iodonium analogs having anticancer and anti-inflammatory activity.

The present invention relates to a novel process for preparing substituted biphenylamides of the general formula (V)

##STR00001## characterized in that anilides of the formula (II)

##STR00002## in a solvent other than tetrahydrofuran, are reacted with an organoboron compound of the formula (III)

##STR00003## in the presence of a catalyst system consisting of a ruthenium catalyst, an activator, an oxidizing agent and a metal triflate.

The present invention relates to a novel process for preparing substituted biphenylamides of the general formula (V)

##STR00001## characterized in that anilides of the formula (II)

##STR00002## in a solvent other than tetrahydrofuran, are reacted with an organoboron compound of the formula (III)

##STR00003## in the presence of a catalyst system consisting of a ruthenium catalyst, an activator, an oxidizing agent and a metal triflate.

The present invention relates to a novel process for preparing substituted biphenylamides of the general formula (V)

##STR00001## characterized in that anilides of the formula (II)

##STR00002## in a solvent other than tetrahydrofuran, are reacted with an organoboron compound of the formula (III)

##STR00003## in the presence of a catalyst system consisting of a ruthenium catalyst, an activator, an oxidizing agent and a metal triflate.

Disclosed herein are novel iodonium analogs having anticancer and anti-inflammatory activity.

Disclosed herein are novel iodonium analogs having anticancer and anti-inflammatory activity.

Described herein are compounds, and pharmaceutically acceptable salts and prodrugs thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound of the invention selectively inhibits a parasitic IMPDH versus a host IMPDH. Further, the invention provides pharmaceutical compositions comprising one or more compounds of the invention. The invention also relates to methods of treating various parasitic and bacterial infections in mammals. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.

Described herein are compounds, and pharmaceutically acceptable salts and prodrugs thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound of the invention selectively inhibits a parasitic IMPDH versus a host IMPDH. Further, the invention provides pharmaceutical compositions comprising one or more compounds of the invention. The invention also relates to methods of treating various parasitic and bacterial infections in mammals. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.