C07C233/15

NOVEL THYROMIMETICS WITH A BIPHENYLMETHANE SCAFFOLD AND THEIR USE

The invention concerns a compound of Formula (I) or a salt thereof, wherein R.sub.1 is H, (C.sub.1-C.sub.3)alkyl or CF.sub.3; R.sub.2 is H, (C.sub.1-C.sub.3)alkyl or CF.sub.3; A is CH.sub.2COOH, XCH.sub.2COOCH.sub.2CH.sub.3, XCH.sub.2COOH, XCH.sub.2CH.sub.2NH.sub.2, where X is nitrogen or oxygen atom; Ar is an aromatic fragment selected from the group consisting of (Ar1), (Ar2) and (Ar3); where R.sub.3 is H, —CH.sub.3, —CH.sub.2CH.sub.3 or CH.sub.3CO—, R.sub.4 is H or —CH.sub.3, R5 is H or —CH.sub.3, and R.sub.6 is H or —CH.sub.3. The compounds of Formula (I) can be used in the treatment of diseases modulated by thyroid hormone receptor-beta (TRb or TRβ).

N-(7-fluoro-1,1,3-trimethyl -1 H-inden-4yl) amides and a process for preparing same

The present invention relates to N-(7-fluoro-1,1,3-trimethyl-1H-inden-4yl) amides and a process for preparing same. The novel amides are useful in a process for converting the unwanted S enantiomer form of a 4-aminoindane derivative to its useful raceme.

N-(7-fluoro-1,1,3-trimethyl -1 H-inden-4yl) amides and a process for preparing same

The present invention relates to N-(7-fluoro-1,1,3-trimethyl-1H-inden-4yl) amides and a process for preparing same. The novel amides are useful in a process for converting the unwanted S enantiomer form of a 4-aminoindane derivative to its useful raceme.

N-(7-fluoro-1,1,3-trimethyl -1 H-inden-4yl) amides and a process for preparing same

The present invention relates to N-(7-fluoro-1,1,3-trimethyl-1H-inden-4yl) amides and a process for preparing same. The novel amides are useful in a process for converting the unwanted S enantiomer form of a 4-aminoindane derivative to its useful raceme.

Device and method for the desalination of water by means of thermal deionisation and liquid-phase ion extraction liquid

Disclosed is a method for treating water, including the extraction of at least two ionic species, the ionic species including an anionic species and a cationic species and being present in the water to be treated, the method especially including a step of mixing a liquid hydrophobic organic phase and the water to be treated, the water to be treated being in the liquid state, in order to subsequently obtain liquid treated water and a hydrophobic liquid organic phase loaded with the ionic species, and a step of thermal regeneration of the organic phase loaded with chemical species. Also disclosed are compounds and compositions that can be used in the method.

Device and method for the desalination of water by means of thermal deionisation and liquid-phase ion extraction liquid

Disclosed is a method for treating water, including the extraction of at least two ionic species, the ionic species including an anionic species and a cationic species and being present in the water to be treated, the method especially including a step of mixing a liquid hydrophobic organic phase and the water to be treated, the water to be treated being in the liquid state, in order to subsequently obtain liquid treated water and a hydrophobic liquid organic phase loaded with the ionic species, and a step of thermal regeneration of the organic phase loaded with chemical species. Also disclosed are compounds and compositions that can be used in the method.

Substituted carboxamides as inhibitors of WDR5 protein-protein binding

The present application is directed to compounds of Formula I: compounds comprising these compounds and their uses, for example as medicaments for the treatment of diseases, disorders or conditions mediated or treatable by inhibition of binding between WDR5 protein and its binding partners. ##STR00001##

Process for converting S-enantiomer to its racemic form

The present invention relates to a novel process for converting the unwanted S enantiomer form to its useful raceme with respect to a 4-aminoindane derivative and to novel intermediates of said process.

Process for converting S-enantiomer to its racemic form

The present invention relates to a novel process for converting the unwanted S enantiomer form to its useful raceme with respect to a 4-aminoindane derivative and to novel intermediates of said process.

Process for converting S-enantiomer to its racemic form

The present invention relates to a novel process for converting the unwanted S enantiomer form to its useful raceme with respect to a 4-aminoindane derivative and to novel intermediates of said process.