Analgesic compounds for treatment of pain or fever that include a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering a compound described herein.

Analgesic compounds for treatment of pain or fever, comprising a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering the compounds.

Analgesic compounds for treatment of pain or fever, comprising a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering the compounds.

Pharmaceutical compounds have anti-inflammatory activity. A pharmaceutical composition may include a therapeutically effective amount of the compound(s) and a pharmaceutically acceptable vehicle. A method of treating a disorder associated with chronic inflammation, such as arthritis, involves administering the pharmaceutical composition to an individual in need thereof.

Pharmaceutical compounds have anti-inflammatory activity. A pharmaceutical composition may include a therapeutically effective amount of the compound(s) and a pharmaceutically acceptable vehicle. A method of treating a disorder associated with chronic inflammation, such as arthritis, involves administering the pharmaceutical composition to an individual in need thereof.

A catalyst composition comprising a monoester, the compound represented by formula (I) as an internal electron donor, and optionally an additional internal electron donor selected from a group consisting of diesters and diethers, ##STR00001##
wherein: R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are hydrogen, straight, branched and cyclic alkyl having at most 20 carbon atoms and aromatic substituted and unsubstituted hydrocarbyl having 6 to 20 carbon atoms, R.sub.7 is a straight, branched and cyclic alkyl having at most 20 carbon atoms and aromatic substituted and unsubstituted hydrocarbyl having 6 to 20 carbon atoms, and R.sub.8 is an aromatic substituted and unsubstituted hydrocarbyl having 6 to 20 carbon atoms. Also described is a process for preparing the polymerization catalyst composition, a polymerization catalyst system comprising the catalyst composition, a co-catalyst and optionally an external electron donor; and use of the catalyst system for polymerization of olefins.

A catalyst composition comprising a monoester, the compound represented by formula (I) as an internal electron donor, and optionally an additional internal electron donor selected from a group consisting of diesters and diethers, ##STR00001##
wherein: R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are hydrogen, straight, branched and cyclic alkyl having at most 20 carbon atoms and aromatic substituted and unsubstituted hydrocarbyl having 6 to 20 carbon atoms, R.sub.7 is a straight, branched and cyclic alkyl having at most 20 carbon atoms and aromatic substituted and unsubstituted hydrocarbyl having 6 to 20 carbon atoms, and R.sub.8 is an aromatic substituted and unsubstituted hydrocarbyl having 6 to 20 carbon atoms. Also described is a process for preparing the polymerization catalyst composition, a polymerization catalyst system comprising the catalyst composition, a co-catalyst and optionally an external electron donor; and use of the catalyst system for polymerization of olefins.

The present invention relates to a process for preparing a catalyst component for polymerization of an olefin comprising the steps of: i) contacting a compound R.sup.9.sub.zMgXz.sub.2-z wherein R.sup.9 is aromatic, aliphatic or cyclo-aliphatic group containing up to 20 carbon atoms, X is a halide, and z is in a range of larger than 0 and smaller than 2, with an alkoxy- or aryloky-containing silane compound pound to given first intermediate reaction product; ii) contacting the first intermediate reaction product with at least one activating compound selected from the group formed by electron donors and compounds of formula M(OR.sup.10).sub.v-w(OR.sup.11).sub.w, wherein M can be Ti, Zr, HI, Al or Si, and M(OR.sup.10).sub.v-w(R.sup.11).sub.w, wherein M is Si, each R.sup.10 and R.sup.11, independently, represent an alkyl, alkenyl or aryl group, v is the valency of M, v being either 3 or 4, and w is smaller than v, to give a second intermediate reaction product; and iii) contacting the second intermediate reaction product with a halogen-containing Ti-compound, a monoester as activating agent, a 1,3-diether as an internal electron donor, and optionally a diester as an additional internal electron donor.

A process for preparing a catalyst component, including: contacting a compound R.sup.9.sub.zMgX.sub.2-z wherein R.sup.9 is aromatic, aliphatic or cyclo-aliphatic group containing up to 20 carbon atoms, X is a halide, and z is larger than 0 and smaller than 2, with an alkoxy- or aryloxy-containing silane compound to give a first intermediate reaction product; contacting the first intermediate reaction product with at least one activating compound selected electron donors, compounds of formula M(OR.sup.10).sub.v-w(OR.sup.11).sub.w, wherein M is Ti, Zr, Hf, Al or Si, and M(OR.sup.10).sub.v-w(R.sup.11).sub.w wherein M is Si, each R.sup.10 and R.sup.11, independently, represent an alkyl, alkenyl or aryl group, v is the valency of M, v is 3 or 4, and w is less than v, to give a second intermediate reaction product; and contacting the second intermediate reaction product with a halogen-containing Ti-compound, a monoester as activating agent, and a 1,3-diether as an internal electron donor.

A process for preparing a catalyst component, including: contacting a compound R.sup.9.sub.zMgX.sub.2-z wherein R.sup.9 is aromatic, aliphatic or cyclo-aliphatic group containing up to 20 carbon atoms, X is a halide, and z is larger than 0 and smaller than 2, with an alkoxy- or aryloxy-containing silane compound to give a first intermediate reaction product; contacting the first intermediate reaction product with at least one activating compound selected electron donors, compounds of formula M(OR.sup.10).sub.v-w(OR.sup.11).sub.w, wherein M is Ti, Zr, Hf, Al or Si, and M(OR.sup.10).sub.v-w(R.sup.11).sub.w wherein M is Si, each R.sup.10 and R.sup.11, independently, represent an alkyl, alkenyl or aryl group, v is the valency of M, v is 3 or 4, and w is less than v, to give a second intermediate reaction product; and contacting the second intermediate reaction product with a halogen-containing Ti-compound, a monoester as activating agent, and a 1,3-diether as an internal electron donor.