A plenoptic endoscope includes a fiber bundle with a distal end configured to receive light from a target imaging region, a sensor end disposed opposite the distal end, and a plurality of fiber optic strands each extending from the distal end to the sensor end. The plenoptic endoscope also includes an image sensor coupled to the sensor end of the fiber bundle, and a plurality of microlenses disposed between the image sensor and the sensor end of the fiber bundle, the plurality of microlens elements forming an array that receives light from one or more of the plurality of fiber optic strands of the fiber bundle and directs the light onto the image sensor. The plurality of microlens elements and the image sensor together form a plenoptic camera configured to capture information about a light field emanating from the target imaging region.

Offset illumination using multiple emitters in a fluorescence imaging system is described. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The emitter comprises a first emitter and a second emitter for emitting different wavelengths of electromagnetic radiation. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises a laser mapping pattern.

An image acquisition system includes: a first narrowband light source that emits first narrowband light for exciting a luminescent agent that exists in an observation target and emits light having a wavelength belonging to a visible light wavelength band; a second narrowband light source that emits second narrowband light in a wavelength band of ±30 nm of a peak light emission wavelength of the luminescent agent; a broadband light source that emits broadband light for illuminating the observation target; a first image sensor on which an image of light in a light emission wavelength band including a wavelength corresponding to light emitted from the luminescent agent is formed; and a second image sensor including one or more image sensors on which an image of light in a wavelength band other than the light emission wavelength band is formed.

A system for imaging and examination of a cervix, comprising a control module connectable with a changeable head configured to image the cervix and collect a tissue biopsy, the head selected from a group consisting of a digital colposcope module, a transvaginal optical probe module and an endo-cervical endoscope module. The system may additionally comprise light source(s) to illuminate cervix tissue; sensing device(s) to generate signal(s) from light and/or to acquire image(s) of a portion of a cervix; and processor(s) in communication with the sensing device(s). The system is configured to: (i) analyze the signal(s); (ii) detect the size of the cervix; (iii) determine parameters defining properties of the cervix; (iv) determine and distinguish normal tissue from abnormal tissue within the cervix; (v) determine the location of area(s) of abnormal tissue in the cervix; and (vi) generate a panoramic view of the cervix.

Architecture and methodology of imaging systems are provided for multispectral tissue imaging with various embodiments. The architectural designs comprise hardware of multispectral light engines and cameras and software of image acquisition, processing, modeling, visualization, and quantification. Embodiments of imaging hardware in a medical device can include a light engine of multiple sources for noncoherent light for visible and fluorescence imaging and coherent light of very narrow bandwidths for laser speckle imaging. The imaging software can include anatomical imaging by visible light, blood perfusion imaging by fluorophores in blood, blood flow distribution imaging by light of high coherence, blood oxygen saturation imaging by light absorption in tissues and tissue composition imaging by light scattering in tissues based on the radiative transfer model of light-tissue interaction. Form factors in medical devices include endoscopic, laparoscopic, arthroscopic devices in medical tower or robot systems, cart device, and handheld scanning or tablet devices.

An imaging probe comprises a camera or endoscope with an external detector array, in which the probe is sized and shaped for surgical placement in an eye to image the eye from an interior of the eye during treatment. The imaging probe and a treatment probe can be coupled together with a fastener or contained within a housing. The imaging probe and the treatment probe can be sized and shaped to enter the eye through an incision in the cornea and image one or more of the ciliary body band or the scleral spur. The treatment probe may comprise a treatment optical fiber or a surgical placement device to deliver an implant. A processor coupled to the detector can be configured with instructions to identify a location of one or more of the ciliary body band, the scleral spur, Schwalbe's line, or Schlemm's canal from the image.

A medical signal processing device includes: an acquisition unit is configured to acquire a first image signal acquired by emission of first light onto an object, and a second image signal acquired by emission of second light onto the object, the first light being in a wavelength band including visible light, and the second light exciting a fluorescent substance included in the object; a detection unit configured to detect each of a signal level of the visible light included in the first image signal and a signal level of fluorescence included in the second image signal; and a calculation unit configured to calculate a correction coefficient to correct the signal level of the fluorescence by using a result of the detection by the detection unit.

There is provided herein a flexible electronic circuit board for a tip section of a multi-camera endoscope, the circuit board comprising a front camera surface configured to carry a forward looking camera, a first side camera surface configured to carry a first side looking camera, a second side camera surface configured to carry a second side looking camera, one or more front illuminator surfaces a configured to carry one or more front illuminators to essentially illuminate the FOV of the forward looking camera, one or more side illuminator surfaces configured to carry one or more side illuminators to essentially illuminate the FOV of the first side looking camera and one or more side illuminator surfaces configured to carry one or more side illuminators to essentially illuminate the FOV of the second side looking camera.

Endoscopic camera head devices and methods are provided using light captured by an endoscope system. Substantially afocal light from the endoscope is manipulated and split. After passing through focusing optics, another beamsplitter is used to split the light again, this time in image space, producing four portions of light that may be further manipulated. The four portions of light are focused onto separate areas of two image sensors. The manipulation of the beams can take several forms, each offering distinct advantages over existing systems when individually displayed, analyzed and/or combined by an image processor.

The present invention provides a protective sheath, a hysteroscope equipped therewith, and a nephroscope equipped with the same, used to prevent contaminants from contaminating electrical connecting lines connected to the endoscope. The protective sheath includes an inner sheath (1) and an outer sheath (2), which are sleeved together, the outer sheath (2) has a cylindrical structure, the inner sheath (1) includes a straight cylindrical portion and a bell mouth portion, the bell mouth portion is located on an insertion end side of the inner sheath (1), a side wall of the bell mouth portion is provided with a plurality of grooves extending from the bell mouth portion to the straight cylindrical portion, and a plurality of elastic sheets (12) are formed at the insertion end of the inner sheath (1); a connecting portion cooperating with a self-locking quick connector (7) is formed on the inner wall of each elastic sheet (12); and a hollow cavity is disposed between the inner sheath (1) and the outer sheath (2), and a compressed waterproof jacket (3) is disposed in the hollow cavity, one end of the waterproof jacket (3) is fixedly sheathed on the inner sheath (1), and the other end of the waterproof jacket (3) can be pulled through a non-insertion end of the protective sheath. The protective sheath is lightweight, compact, and easy to operate. The protective sheath effectively protects the electrical connecting lines from being contaminated during use, thereby preventing short circuit, contamination and other situations, furthermore, the protective sheath is low in production cost and can be used as a disposable medical device.