The present disclosure relates to biomimetic nanomaterials, compounds, compositions, and methods for delivery of therapeutic, diagnostic, or prophylactic agents (for example, a nucleic acid).

What is described is a method of synthesis of the compound of formula 1A,

##STR00001## or a salt thereof, wherein R.sub.3 is a linear or branched alkene of 1, 2, 3, 4, 5 or 6 carbons; R.sub.4 and R.sub.5 are the same or different, each a hydrogen, or a linear or branched alkyl of 1, 2, 3, 4, 5 or 6 carbons; and L.sub.3 is a bond or an alkane of 1, 2, 3, 4, 5 or 6 carbons.

What is described is a method of synthesis of the compound of formula 1A,

##STR00001## or a salt thereof, wherein R.sub.3 is a linear or branched alkene of 1, 2, 3, 4, 5 or 6 carbons; R.sub.4 and R.sub.5 are the same or different, each a hydrogen, or a linear or branched alkyl of 1, 2, 3, 4, 5 or 6 carbons; and L.sub.3 is a bond or an alkane of 1, 2, 3, 4, 5 or 6 carbons.

The present invention relates to a bifunctional chiral organocatalytic compound having excellent enantioselectivity, a preparation method therefor, and a method for producing a non-natural gamma amino acid from a nitro compound by using the chiral organocatalytic compound. According to the present invention, the bifunctional chiral organocatalytic compound having excellent enantioselectivity can be easily synthesized, gamma-amino acids with high optical selectivity can be obtained at a high yield by an economical and convenient method using the chiral organocatalytic compound, and various (R)-configuration gamma-amino acids, which are not present in nature, can be produced with high optical purity in large quantities by using a small amount of a catalyst, and therefore, the present invention can be widely utilized in various industrial fields including the pharmaceutical industry.

A novel branched fluorine-containing compound represented by formula (1):

(RfY.sub.n1LX-A).sub.n2(1)

wherein L represents a predetermined carbon-containing linker moiety; Rf, in each occurrence, is the same or different and represents fluoroalkyl optionally having at least one ether bond; Y, in each occurrence, is the same or different and represents a predetermined divalent linking group or a bond; R.sup.Y, in each occurrence, is the same or different and represents hydrogen or an organic group; L represents an (n1+n2)-valent carbon-containing linker moiety having at least one carbon atom; n1 represents a number greater than or equal to 1; n2 represents a number greater than or equal to 1; n1+n2 is a number from 3 to 6; X, in each occurrence, is the same or different and represents a divalent linking group or a bond; A, in each occurrence, is the same or different and represents ArSO.sub.3M or the like; M, in each occurrence, is the same or different and represents hydrogen, NR.sub.4, or a metal salt; and R represents hydrogen or a C.sub.1-4 organic group.

A novel branched fluorine-containing compound represented by formula (1):

(RfY.sub.n1LX-A).sub.n2(1)

wherein L represents a predetermined carbon-containing linker moiety; Rf, in each occurrence, is the same or different and represents fluoroalkyl optionally having at least one ether bond; Y, in each occurrence, is the same or different and represents a predetermined divalent linking group or a bond; R.sup.Y, in each occurrence, is the same or different and represents hydrogen or an organic group; L represents an (n1+n2)-valent carbon-containing linker moiety having at least one carbon atom; n1 represents a number greater than or equal to 1; n2 represents a number greater than or equal to 1; n1+n2 is a number from 3 to 6; X, in each occurrence, is the same or different and represents a divalent linking group or a bond; A, in each occurrence, is the same or different and represents ArSO.sub.3M or the like; M, in each occurrence, is the same or different and represents hydrogen, NR.sub.4, or a metal salt; and R represents hydrogen or a C.sub.1-4 organic group.

The present invention relates to a composition for clearing a biotissue and a method for clearing a biotissue using thereof.

The present invention relates to a composition for clearing a biotissue and a method for clearing a biotissue using thereof.

This invention provides preparations, compositions, products, and applications of photo-crosslinked hydrogels. Component Aa photosensitive polymer derivative, component Bthe photoinitiator, and auxiliary component Cother biocompatible polymer derivative each are respectively dissolved in a biocompatible medium to obtain solution A, solution B, and solution C. The solution A, the solution B, and the optional solution C are mixed homogenously to obtain a hydrogel precursor solution. The hydrogel precursor solution is subject to irradiation of the UV light for photocoupled crosslinking to form a photo-crosslinked hydrogel. The photo-crosslinked hydrogel exhibit rapid speed of photo-curing, strong tissue adhesion, excellent mechanical properties, good biocompatibility, and excellent clinical operability. In addition, this invention also provides a kit for making the photo-crosslinked hydrogel, and applications thereof in tissue engineering, regenerative medicine, 3D printing, and as a carrier of cell, protein, or drug.

This invention provides preparations, compositions, products, and applications of photo-crosslinked hydrogels. Component Aa photosensitive polymer derivative, component Bthe photoinitiator, and auxiliary component Cother biocompatible polymer derivative each are respectively dissolved in a biocompatible medium to obtain solution A, solution B, and solution C. The solution A, the solution B, and the optional solution C are mixed homogenously to obtain a hydrogel precursor solution. The hydrogel precursor solution is subject to irradiation of the UV light for photocoupled crosslinking to form a photo-crosslinked hydrogel. The photo-crosslinked hydrogel exhibit rapid speed of photo-curing, strong tissue adhesion, excellent mechanical properties, good biocompatibility, and excellent clinical operability. In addition, this invention also provides a kit for making the photo-crosslinked hydrogel, and applications thereof in tissue engineering, regenerative medicine, 3D printing, and as a carrier of cell, protein, or drug.