According to some aspects, a medical imaging system is provided. The medical imaging system includes an illumination device and a medical imaging device. The illumination device includes a first light source configured to emit first light having a wavelength range. The illumination device further includes a second light source configured to emit second light having at least one predetermined wavelength band. The at least one predetermined wavelength band is within the wavelength range. The illumination device further includes a dichroic mirror configured to attenuate a portion of the wavelength range corresponding to the at least one predetermined wavelength band and to multiplex the second light with the first light such that the portion of the wavelength range of the first light is attenuated. The light multiplexed by the dichroic mirror is emitted from the illumination device along an optical axis and irradiates an observation site. The medical imaging device includes at least one sensor configured to receive light from the observation site.

Improved fluoresced imaging (FI) endoscope devices and systems are provided to enhance use of endoscopes with FI and visible light capabilities. An endoscope device is provided for endoscopy imaging in a white light and a fluoresced light mode. A relay system includes an opposing pair of rod lens assemblies positioned symmetrically with respect to a central airspace. The rod lens assemblies include a meniscus lens positioned immediately adjacent to a central airspace and with the convex surface facing the airspace, a first lens having positive power with a convex face positioned adjacent to the inner face of the meniscus lens, a rod lens adjacent to the first lens having positive power and an outer optical manipulating structure selected from various designs providing chromatic aberration correction.

The disclosed embodiments relate to a system that implements a side-viewing imaging catheter. This system includes a catheter sheath enclosing an imaging core, wherein the imaging core resents an internal optical channel coupled to an optical element located at the distal end of the imaging core. The optical element includes an internal reflective surface that reflects and focuses light transmitted via the optical channel in a direction orthogonal to a rotational axis of the catheter toward a target location, and returns reflected light from the target location back through the optical channel. This internal reflective surface of the optical element is shaped to focus the light so that a resulting beam shape at the target location has a small cross section area and substantially equal axial and transaxial dimensions.

A system for selective spectral illumination in an operating room includes a housing, at least one light source disposed within the housing, the at least one light source configured to emit electromagnetic radiation at a plurality of wavelengths, and a controller coupled to the at least one light source and configured to control the at least one light source to emit electromagnetic radiation at one or more of the plurality of wavelengths based on a status of operation of an optical imaging system in the operating room.

Methods are provided for the highlighting of features in composite images through the alternating of images having complementary colors. An image having a feature of interest is used to generate one or more pseudo color images. A series of a pseudo color images and one or more additional pseudo color or original color images are then alternately displayed so that the differently colored regions among the series of images are easily recognizable to an operator. The differently colored regions differ in having hues that are complementary to one another. The methods are particularly useful for the display of information using two or more imaging modalities and channels, such as is the case for some medical applications in which a natural-light image of pink or light-red tissue with deeper red or blue vasculature is overlaid with another functional image. In these cases, a feature present in the functional image can be more easily perceived when displayed in a composite overlay with an underlying image from another imaging modality or channel.

An objective optical system includes a predetermined lens disposed near the pupil of the objective optical system. The predetermined lens has a first refractive region including an optical axis and a second refractive region located outside the first refractive region. The refractive power of the second refractive region is greater than the refractive power of the first refractive region. A light beam reaching an image plane includes a first light beam and a second light beam. The first light beam is a light beam transmitted through the first refractive region and includes at least one of a beam of white light and a beam of near-infrared light. The second light beam is a light beam transmitted through the second refractive region and includes only the beam of near-infrared light. A predetermined conditional expression (1) is satisfied.

A photodynamic treatment device treating a patient's cervix opening with light that causes selected tissue to fluoresce and imaging the tissue while the treatment is in progress without affecting the treatment.

The invention relates to multicore fiber imaging, such as used in endoscopy. Methods are described for processing images captured with such systems to achieve an improved depth of field image or extract 3D information concerning the images, without requiring the addition of additional optical components. One method for generating an image from light received by an imager via a multiplicity of waveguides includes receiving a digital image containing a plurality of pixels, the digital image including a plurality of regions within it wherein each of said regions corresponds to a waveguide core. Each region includes a plurality of pixels, and a first subset of pixels within each region is defined which at least partly correlates with light having been received at a corresponding core in a first spatial arrangement, the subset including less than all of the pixels within a region. A first image is generated from the first subset of pixels from said regions, combined to form an image over the whole waveguide array. The first spatial arrangement may correspond to a measure of angular dimension of the incident light for that region. In addition to increased depth of field, the modified images provided by the invention allow 3D visualisation of objects, eg. using stereographs or depth mapping techniques.

An imaging system includes a light source for emitting visible light and infrared light and a camera head unit configured to capture visible light image data so as to generate a visible light image frame and configured to capture infrared image data so as to generate an infrared image frame. A camera control unit is configured to extract a structural data from the visible light image frame. The camera control unit is further configured to apply the structural data to the infrared image frame so as to enhance the infrared image with structural data.

Pulsed fluorescence imaging in a light deficient environment is disclosed. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The system includes a controller configured to synchronize timing of the emitter and the image sensor. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises electromagnetic radiation having a wavelength from about 795 nm to about 815 nm.