Systems, devices, methods, and program products are provided for operating a medical system that is operable within at least two different medical device regulatory classes. A device control module receives an indicator for performing at least one procedure with a medical device. Based on the indicator, it selects a binary image for booting the control module from among multiple images including a controlled-type and a non-controlled type, which operate in different regulatory classes. A controlled-type image, which may be FDA PMA or other regulatory classes, is verified to be unaltered, and is then used to operate as a regulated medical device. The indicator can be automatic or manual. The indicator may result from connection of a specific medical device or peripheral device, or may be user input.

An optical system for an endoscope includes an objective and a reversal system arranged after the objective. The reversal system includes at least one reversal stage for projecting the distal intermediate image as a proximal intermediate image into a proximal intermediate image plane. The reversal system imprints on the proximal intermediate image a first longitudinal chromatic aberration referred to a predetermined wavelength from the visible spectrum and a predetermined wavelength from the near infrared range. The objective imprints on the distal intermediate image a second longitudinal chromatic aberration referred to the predetermined wavelength from the visible spectrum and the predetermined wavelength from the near infrared range. The second longitudinal chromatic aberration has the opposite sign relative to the first longitudinal chromatic aberration, which reduces the longitudinal chromatic aberration caused by the reversal system in the proximal intermediate image.

Driving an emitter to emit pulses of electromagnetic radiation according to a jitter specification in a hyperspectral, fluorescence, and laser mapping imaging system is described. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The system includes a driver for driving emissions by the emitter according to a jitter specification. The system is h that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises one or more of a hyperspectral emission, a fluorescence emission, and/or a laser mapping pattern.

The present invention belongs to the technical field of medical instruments, and discloses a multifunctional compound light penetration enhanced imaging system and an enhanced imaging method. The structural design of the present invention is reasonable. Through the cooperation of the first working channel tube, the second working channel tube, and the third working channel tube, the size of the channel is switched. When the system shrinks to the minimum, the opening size of the wound is only 1/3 of that when the system is fully opened, which is suitable for a double-channel spinal endoscopic surgery. When the system is expanded to the maximum, it is suitable for transforaminal endoscopic surgery, and is suitable for multiple surgical modes. By adding a special red light component on the basis of the white light to form compound light illumination and increase the system transmittivity, the background penetration is realized.

Systems, methods, and devices for fluorescence imaging with a minimal area image sensor are disclosed. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation, wherein the pixel array comprises active pixels and optical black pixels. The system includes a black clamp circuit providing offset control for data generated by the pixel array and a controller comprising a processor in electrical communication with the image sensor and the emitter. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises electromagnetic radiation having a wavelength from about 795 nm to about 815 nm.

Closed cavity adjustable sensor mount systems and methods are disclosed. The sensor mount systems include a sealed, closed cavity enclosing a sensor and forming a closed cavity sensor assembly. The closed cavity sensor assembly may be tilted and/or translated relative to a platform in order to adjust the orientation of the sensor to align it with an imaging optical axis. Following alignment, the closed cavity sensor assembly may be permanently or reversibly fixed in place. The closed cavity adjustable sensor mount systems may be part of medical imaging systems such as endoscopic imaging systems and/or open field imaging systems.

Provided is a biological tissue observation apparatus including an optical fiber probe that receives fluorescence via an input end disposed at one end thereof and that optically guides the fluorescence toward the base end in the longitudinal direction, a photodetector that is disposed facing an output end disposed at the base end of the optical fiber probe and that detects the fluorescence output from the output end, and a scatter suppressing unit provided near the input end of the optical fiber probe.

An imaging device includes a light splitting unit which splits first light from a subject into second light and third light, first and second imaging units, and an arithmetic unit. The first light includes the second light having infrared light and at least one of green light and blue light, and the third light having red light or the green light. The first imaging unit includes a first and a second light reception regions. The first light reception region generates at least one of the group consisting of a B signal according to the blue light and a G signal according to the green light. The second light reception region generates an IR signal according to the infrared light. The arithmetic unit generates a visible light image signal from the R signal, the G signal, and the B signal and generates an infrared light image signal from the IR signal.

The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

The invention, in some aspects, relates to polypeptide molecules and their encoding nucleic acid molecules and use of such molecules to direct and localize sensor molecules in the soma of cells in which they are expressed. Compositions of the invention may be delivered to cells and subjects and used in methods to determine activity in cells in which they are expressed.