The present invention provides novel cannabinoid derivatives, methods for their preparation, pharmaceutical compositions comprising same, and methods of use thereof as medicaments.

The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.

The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.

The present disclosure provides a novel fluorine-containing compound which has a moiety derived from a compound (a) that has one or more active hydrogen-containing groups selected from among a hydroxy group, an amino group, a carboxyl group and a thiol group, and a moiety derived from a compound (b) that has R.sup.f1 or R.sup.f2, wherein: R.sup.f1 is CF.sub.3, CF.sub.2H or CFH.sub.2; R.sup.f2 is CF.sub.2 or CFH; and R.sup.f1 and R.sup.f2 are not parts of a fluoroalkyl group having 2 or more carbon atoms.