An object of the present invention is to provide an aldehyde compound and an ester compound that both have difluoro at the -position, a double bond or epoxy at the -position, and a disubstituted alkene at the -position. Provided are difluoroaldehyde, epoxy, and derivatives thereof.

An object of the present invention is to provide an aldehyde compound and an ester compound that both have difluoro at the -position, a double bond or epoxy at the -position, and a disubstituted alkene at the -position. Provided are difluoroaldehyde, epoxy, and derivatives thereof.

Novel ionizable lipids and lipid nanoparticles that can be used in the delivery of therapeutic cargos are disclosed.

Novel ionizable lipids and lipid nanoparticles that can be used in the delivery of therapeutic cargos are disclosed.