The present invention relates to alpha hydroxy amides including compounds of formula I: ##STR00001##
and related compounds and their use in the prophylaxis and treatment of inflammatory disorders and diseases, wherein T.sup.1, T.sup.2, W and R.sup.W have the meanings given in claim 1.

The present invention relates to alpha hydroxy amides including compounds of formula I: ##STR00001##
and related compounds and their use in the prophylaxis and treatment of inflammatory disorders and diseases, wherein T.sup.1, T.sup.2, W and R.sup.W have the meanings given in claim 1.

Fumarate compounds, pharmaceutical compositions comprising the fumarate compounds, and methods of using fumarate compounds and pharmaceutical compositions for treating neurodegenerative, inflammatory, and autoimmune disorders including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are disclosed.

The present disclosure relates to novel cinnamamide derivatives and use thereof in preventing or treating cancer.

The present disclosure relates to novel cinnamamide derivatives and use thereof in preventing or treating cancer.

The present invention relates to a pharmaceutical composition and a cosmetic composition, which contain, as an active ingredient, a novel pseudo compound having similar structural characteristics to natural ceramide 1, or a pharmaceutically acceptable salt or solvate thereof, and the composition containing the compound of the present invention as an active ingredient has an excellent effect of enhancing a skin barrier function, thereby exhibiting an effect of alleviating inflammatory skin diseases, and has an excellent skin barrier improving function and an excellent skin moisturization enhancing effect.

The present invention relates to a pharmaceutical composition and a cosmetic composition, which contain, as an active ingredient, a novel pseudo compound having similar structural characteristics to natural ceramide 1, or a pharmaceutically acceptable salt or solvate thereof, and the composition containing the compound of the present invention as an active ingredient has an excellent effect of enhancing a skin barrier function, thereby exhibiting an effect of alleviating inflammatory skin diseases, and has an excellent skin barrier improving function and an excellent skin moisturization enhancing effect.

This invention provides a compound having the structure ##STR00001##
wherein , , X, Y, and R.sub.1-R.sub.11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF-B activation in a population of cells.

This invention provides a compound having the structure ##STR00001##
wherein , , X, Y, and R.sub.1-R.sub.11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF-B activation in a population of cells.

This document discloses molecules having the following formula (Formula One):

##STR00001##

and processes associated therewith.