The present invention provides compounds and methods for the treatment and prevention of diseases and conditions associate with or aggravated by impaired mitophagy.

The present invention provides compounds and methods for the treatment and prevention of diseases and conditions associate with or aggravated by impaired mitophagy.

The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.

The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.

Disclosed is an organic amine salt foaming agent, that is, a composite polyurethane foaming agent, comprising: 1) hexafluorobutene; and 2) an alkanolamine salt mixture (MAA), the alkanolamine salt mixture (MAA) contains an organic amine salt compound having the following general formula (I): A.sup.n[B.sup.m+].sub.p (I); wherein A.sup.n is one or two or three selected from the following anions: (b) carbonate: CO.sub.3.sup.2; (c) formate: HCOO.sup.; (d) bicarbonate: HOCOO.sup.. A polyurethane foaming method using carbon dioxide and an organic amine in combination is also disclosed, in which carbon dioxide is added to a polyurethane composition for foaming. A method for preparing an alkanolamine carbonate salt with low water content from ammonium carbonate and an epoxide is additionally disclosed, in which a liquid alkanolamine salt mixture is used as a dispersion medium or as a solvent for reaction raw material.

A polymerizable compound has a practical low melting point, excellent solubility in a general-purpose solvent, and can produce an optical film at low cost, exhibits low reflected luminance, and achieves uniform conversion of polarized light over a wide wavelength band, an optically anisotropic article.

A compound 3,3-(hydrazine-1,2-diyl)bis(1-(naphthalen-2-yloxy)propan-2-ol), its synthesis, and its use as an insecticidal agent.

A compound 3,3-(hydrazine-1,2-diyl)bis(1-(naphthalen-2-yloxy)propan-2-ol), its synthesis, and its use as an insecticidal agent.

A polymerizable compound has a practical low melting point, excellent solubility in a general-purpose solvent, and can produce an optical film at low cost, exhibits low reflected luminance, and achieves uniform conversion of polarized light over a wide wavelength band, an optically anisotropic article.

The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.