The invention provides a compound of Formula I: ##STR00001##
or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.

The invention provides a compound of Formula I: ##STR00001##
or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.

A self-crosslinking compound and coating compositions including the same as well as compositions capable of forming a ketone or carbonyl-hydrazide crosslink at ambient temperatures that utilizes a modified latent cross linker capable of forming a polymer networked in an applied coating.

A self-crosslinking compound and coating compositions including the same as well as compositions capable of forming a ketone or carbonyl-hydrazide crosslink at ambient temperatures that utilizes a modified latent cross linker capable of forming a polymer networked in an applied coating.

Presently describes are hydrazide (e.g. dihydrazide) compounds suitable for use as a nucleating agent for a polylactic acid (PLA) polymer. Also described are articles such as a film or fiber comprising the semicrystalline polylactic acid polymer and a nucleating agent.

Presently describes are hydrazide (e.g. dihydrazide) compounds suitable for use as a nucleating agent for a polylactic acid (PLA) polymer. Also described are articles such as a film or fiber comprising the semicrystalline polylactic acid polymer and a nucleating agent.

The present invention relates to compounds of formula (I) and to pharmaceutical compositions containing them:

##STR00001##

wherein meanings of the substituents are indicated in the description.

Such compounds for use in the treatment of cancer and other diseases related to altered angiogenesis, such as arthritic pathology, diabetic retinopathy, psoriasis and chronic inflammatory disease, are also within the scope of the present invention.

The invention provides a compound of Formula I:

##STR00001##

or a pharmaceutically acceptable salt thereof as described herin. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.

The invention provides a compound of Formula I:

##STR00001##

or a pharmaceutically acceptable salt thereof as described herin. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.

The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.