Compositions of manganese accumulating plants.

A compound represented by Formula (1): each of L.sup.1 and L.sup.2 independently represents an alkyl group having from 1 to 20 carbon atoms, an alkoxy group having from 1 to 20 carbon atoms, NH.sub.2, NHR.sup.3, NR.sup.3R.sup.4, an ester group, a carboxy group, an amide group, a cyano group, a nitro group, a halogen atom, an acyl group, CF.sub.3, O(CH.sub.2).sub.1OCH.sub.3, a carbamate group, or an aryl group. 1 represents 1 or 2. Each of R.sup.1 and R.sup.2 independently represents a divalent hydrocarbon group having from 1 to 10 carbon atoms, at least one hydrogen atom of the divalent hydrocarbon group is optionally substituted with an alkyl group, an aryl group, an ester group, a carboxy group, an amide group, a cyano group, a nitro group, a halogen atom, an acyl group, CF.sub.3, O(CH.sub.2).sub.1OCH.sub.3, a carbamate group, or an alkoxy group, each of R.sup.3 and R.sup.4 independently represents an alkyl group, an aryl group, an acyl group, an ester group, an alkylsulfonyl group, or an arylsulfonyl group, each of R.sup.5 and R.sup.6 independently represents a hydrogen atom, an alkyl group having from 1 to 20 carbon atoms, or an aryl group, and n+m≥1.

A compound represented by Formula (1): each of L.sup.1 and L.sup.2 independently represents an alkyl group having from 1 to 20 carbon atoms, an alkoxy group having from 1 to 20 carbon atoms, NH.sub.2, NHR.sup.3, NR.sup.3R.sup.4, an ester group, a carboxy group, an amide group, a cyano group, a nitro group, a halogen atom, an acyl group, CF.sub.3, O(CH.sub.2).sub.1OCH.sub.3, a carbamate group, or an aryl group. 1 represents 1 or 2. Each of R.sup.1 and R.sup.2 independently represents a divalent hydrocarbon group having from 1 to 10 carbon atoms, at least one hydrogen atom of the divalent hydrocarbon group is optionally substituted with an alkyl group, an aryl group, an ester group, a carboxy group, an amide group, a cyano group, a nitro group, a halogen atom, an acyl group, CF.sub.3, O(CH.sub.2).sub.1OCH.sub.3, a carbamate group, or an alkoxy group, each of R.sup.3 and R.sup.4 independently represents an alkyl group, an aryl group, an acyl group, an ester group, an alkylsulfonyl group, or an arylsulfonyl group, each of R.sup.5 and R.sup.6 independently represents a hydrogen atom, an alkyl group having from 1 to 20 carbon atoms, or an aryl group, and n+m≥1.

The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.

The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.

Disclosed is a reagent for measuring L-biotin, comprising an optically isomeric biotin-binding site and an azobenzene derivative represented by following formula (I):

##STR00001## wherein R.sub.1 to R.sub.10 are each independently a group selected from the group consisting of a hydrogen atom, a hydroxy group, a carboxy group, C1 to C6 dialkylamino groups having no substituent or a substituted group, C1 to C6 alkyl groups having no substituent or a substituted group, and C1 to C6 alkoxy groups having no substituent or a substituted group, provided that at least one of R.sub.1 to R.sub.5 is a hydroxy group or a C1 to C6 dialkylamino group having no substituent or a substituted group, and at least one of R.sub.6 to R.sub.10 is a carboxy group.

Disclosed is a reagent for measuring L-biotin, comprising an optically isomeric biotin-binding site and an azobenzene derivative represented by following formula (I):

##STR00001## wherein R.sub.1 to R.sub.10 are each independently a group selected from the group consisting of a hydrogen atom, a hydroxy group, a carboxy group, C1 to C6 dialkylamino groups having no substituent or a substituted group, C1 to C6 alkyl groups having no substituent or a substituted group, and C1 to C6 alkoxy groups having no substituent or a substituted group, provided that at least one of R.sub.1 to R.sub.5 is a hydroxy group or a C1 to C6 dialkylamino group having no substituent or a substituted group, and at least one of R.sub.6 to R.sub.10 is a carboxy group.

The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.

The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.

Provided is a compound which accelerates the enzymatic reaction catalyzed by an oxidase. The present invention provides an oxidase reaction accelerating agent comprising a compound represented by formula (I) and a method using the same.