Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V):

##STR00001##

and/or a salt thereof, wherein R.sub.1 is OH or OP(O)(OH).sub.2, and X.sub.1, X.sub.2, X.sub.3, R.sub.2, R.sub.2a, R.sub.a, R.sub.b, and R.sub.c are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P.sub.1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

Described herein are compounds that reactivate acetylcholinesterase and associated methods of treating organophosphate poisoning.

Described herein are compounds that reactivate acetylcholinesterase and associated methods of treating organophosphate poisoning.

The presented invention relates to a process for preparation of compound of formula (I) or a salt or a solvate thereof (i.e.) siponimod. The invention also relates to intermediates used in the process and solid forms of these intermediates. ##STR00001##

Described herein are compounds that reactivate acetylcholinesterase and associated methods of treating organophosphate poisoning.

Described herein are compounds that reactivate acetylcholinesterase and associated methods of treating organophosphate poisoning.

Disclosed are an acetophenone oxime compound and a preparation method therefor, and specifically disclosed are a compound as shown in formula (II) and a pharmaceutically acceptable salt thereof. ##STR00001##

A 2,6-dibenzylidenecyclohexanone oxime compound and a preparation method and use thereof are provided. A structural fragment with anti-inflammatory activity is introduced into the 2,6-dibenzylidenecyclohexanone oxime compound, and the prepared compound has stable physicochemical properties. The 2,6-dibenzylidenecyclohexanone oxime compound has an excellent inhibitory effect on inflammatory factors and better in-vivo anti-inflammatory activity, and especially has a protective effect on hepatitis and fatty liver caused by excessive expression and release of TNF- and/or IL-6, as well as liver inflammation and liver lipid metabolism.

A 2,6-dibenzylidenecyclohexanone oxime compound and a preparation method and use thereof are provided. A structural fragment with anti-inflammatory activity is introduced into the 2,6-dibenzylidenecyclohexanone oxime compound, and the prepared compound has stable physicochemical properties. The 2,6-dibenzylidenecyclohexanone oxime compound has an excellent inhibitory effect on inflammatory factors and better in-vivo anti-inflammatory activity, and especially has a protective effect on hepatitis and fatty liver caused by excessive expression and release of TNF- and/or IL-6, as well as liver inflammation and liver lipid metabolism.