Patent classifications
C07C309/24
INDANES AS PD-L1 INHIBITORS
Compounds represented by Formula (I) or (II):
##STR00001##
are provided herein, or a pharmaceutically acceptable salt, or a prodrug or bioisostere thereof; wherein R.sup.1, R.sup.2a, R.sup.2b, R.sup.2c, R.sup.3, R.sup.4, R.sup.5, R.sup.6a, R.sup.6b, R.sup.2a, R.sup.2b, R.sup.2c, R.sup.3, R.sup.4, R.sup.5, R.sup.6a, Y, Y, and the subscripts m and n are as defined herein.
P-doped conjugated small molecular electrolyte and organic electronic devices using the same
Disclosed are a p-doped conjugated small molecular electrolyte containing a compound represented by Formula 1 and an organic electronic device using the same as a hole transport material.
[Ar.sub.2Ar.sub.1Ar.sub.2].sup.+<Formula 1> wherein, in Formula 1, Ar.sub.1 is any one selected from the following Compound Group 1, Ar.sub.2 is any one selected from the following Compound Group 2a or the following Compound Group 2b, and superscript + in the square bracket indicates an oxidized portion of a main chain of the small molecule.
P-doped conjugated small molecular electrolyte and organic electronic devices using the same
Disclosed are a p-doped conjugated small molecular electrolyte containing a compound represented by Formula 1 and an organic electronic device using the same as a hole transport material.
[Ar.sub.2Ar.sub.1Ar.sub.2].sup.+<Formula 1> wherein, in Formula 1, Ar.sub.1 is any one selected from the following Compound Group 1, Ar.sub.2 is any one selected from the following Compound Group 2a or the following Compound Group 2b, and superscript + in the square bracket indicates an oxidized portion of a main chain of the small molecule.
USE OF TG02 FOR TREATING GLIOMAS IN PEDIATRIC SUBJECTS
The present disclosure relates to uses of TG02, for treating a glioma in a pediatric human subject. In certain embodiments, the glioma can be a pediatric high-grade glioma (PHGG), e.g., a diffuse intrinsic pontine glioma (DIPG), and/or a H3.3-mutated glioma (e.g., a H3K27M-mutated glioma). The present disclosure further provides pharmaceutical compositions and kits that include an ERK5 inhibitor.
Process for preparing unipolar cation-conducting ionomers from difluoro ionic monomers
The invention relates to a process for preparing unipolar cation-conducting ionomers from fluoro ionic monomers, to said unipolar cation-conducting ionomers, to the uses thereof, to an electrolytic composition comprising at least one of said unipolar cation-conducting ionomers and to an electrochemical device comprising at least one of said unipolar cation-conducting ionomers, especially as electrolyte.
Process for preparing unipolar cation-conducting ionomers from difluoro ionic monomers
The invention relates to a process for preparing unipolar cation-conducting ionomers from fluoro ionic monomers, to said unipolar cation-conducting ionomers, to the uses thereof, to an electrolytic composition comprising at least one of said unipolar cation-conducting ionomers and to an electrochemical device comprising at least one of said unipolar cation-conducting ionomers, especially as electrolyte.
Adhesive composition, bio-electrode, method for manufacturing a bio-electrode, and salt
An adhesive composition including a resin and electro-conductive material, wherein the electro-conductive material is an ammonium salt of fluorosulfonic acid having 5 or more carbon atoms shown by the general formula (1): (R.sup.1XZSO.sub.3.sup.).sub.n M.sup.n+ (1), wherein, R.sup.1 represents a monovalent hydrocarbon group having 1 to 40 carbon atoms and optionally substituted by a heteroatom or optionally interposed by heteroatom; X represents any of a single bond, ether group, ester group, and amide group; Z represents an alkylene group having 2 to 4 carbon atoms, containing 1 to 6 fluorine atoms, and optionally containing a carbonyl group; M.sup.n+ represents a cation having one or two ammonium cation structures. This can form a living body contact layer for a bio-electrode with excellent electric conductivity, biocompatibility, and light weight, which manufactures at low cost and does not cause large lowering of the electric conductivity even when it is wetted with water or dried.
Adhesive composition, bio-electrode, method for manufacturing a bio-electrode, and salt
An adhesive composition including a resin and electro-conductive material, wherein the electro-conductive material is an ammonium salt of fluorosulfonic acid having 5 or more carbon atoms shown by the general formula (1): (R.sup.1XZSO.sub.3.sup.).sub.n M.sup.n+ (1), wherein, R.sup.1 represents a monovalent hydrocarbon group having 1 to 40 carbon atoms and optionally substituted by a heteroatom or optionally interposed by heteroatom; X represents any of a single bond, ether group, ester group, and amide group; Z represents an alkylene group having 2 to 4 carbon atoms, containing 1 to 6 fluorine atoms, and optionally containing a carbonyl group; M.sup.n+ represents a cation having one or two ammonium cation structures. This can form a living body contact layer for a bio-electrode with excellent electric conductivity, biocompatibility, and light weight, which manufactures at low cost and does not cause large lowering of the electric conductivity even when it is wetted with water or dried.
Structure, synthesis, and applications for poly (phenylene) ethynylenes (PPEs)
The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.
Structure, synthesis, and applications for poly (phenylene) ethynylenes (PPEs)
The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.