Disclosed are an o-phenyl chalcone compounds and preparation methods and uses thereof. The o-phenyl chalcone compounds are capable of inhibiting the aggregation of microtubules in tumor cells and influencing the mitosis of the cells, and has a high antitumor activity. The compounds also have inhibitory activity against proliferation on various tumor cells, such as a human ovary cancer cell A2780, a human colon cancer cell HCT8, a human breast cancer cell MCF7, a human lung cancer cell A549, a human colon cancer cell SW480, a human nasopharyngeal carcinoma cell CNE2, a human liver cancer cell HepG2 and the like at nanomole concentrations.

A negative resist composition comprising (A) a sulfonium compound of betaine type and (B) a polymer is provided. The resist composition is effective for controlling acid diffusion during the exposure step, exhibits a very high resolution during pattern formation, and forms a pattern with minimal LER.

Disclosed embodiments concern an array for use in identifying or identifying and quantifying analytes in a sample using a macrocyclic sensor comprising a macrocyclic compound and a detectable moiety. The disclosed array may be used to discriminate among various analytes based on different features, such as post-translational modifications, isomeric post-translational modifications, and the peptide sequence around post-translational modifications. Also disclosed is a method for identifying analytes comprising a post-translational modification, as well as an enzymatic assay using the disclosed macrocyclic sensor.

Disclosed embodiments concern an array for use in identifying or identifying and quantifying analytes in a sample using a macrocyclic sensor comprising a macrocyclic compound and a detectable moiety. The disclosed array may be used to discriminate among various analytes based on different features, such as post-translational modifications, isomeric post-translational modifications, and the peptide sequence around post-translational modifications. Also disclosed is a method for identifying analytes comprising a post-translational modification, as well as an enzymatic assay using the disclosed macrocyclic sensor.

Disclosed are an o-phenyl chalcone compounds and preparation methods and uses thereof. The o-phenyl chalcone compounds are capable of inhibiting the aggregation of microtubules in tumor cells and influencing the mitosis of the cells, and has a high antitumor activity. The compounds also have inhibitory activity against proliferation on various tumor cells, such as a human ovary cancer cell A2780, a human colon cancer cell HCT8, a human breast cancer cell MCF7, a human lung cancer cell A549, a human colon cancer cell SW480, a human nasopharyngeal carcinoma cell CNE2, a human liver cancer cell HepG2 and the like at nanomole concentrations.

Disclosed are an o-phenyl chalcone compounds and preparation methods and uses thereof. The o-phenyl chalcone compounds are capable of inhibiting the aggregation of microtubules in tumor cells and influencing the mitosis of the cells, and has a high antitumor activity. The compounds also have inhibitory activity against proliferation on various tumor cells, such as a human ovary cancer cell A2780, a human colon cancer cell HCT8, a human breast cancer cell MCF7, a human lung cancer cell A549, a human colon cancer cell SW480, a human nasopharyngeal carcinoma cell CNE2, a human liver cancer cell HepG2 and the like at nanomole concentrations.

It is an object of the present invention to provide a sulfonic acid group-containing polymer and a sulfonic acid group-containing aromatic compound, which have excellent proton conductivity even under the low humidification condition, are excellent in mechanical strength and chemical stability and, moreover, can attain high output and excellent physical durability when processed into a solid polymer fuel cell, as well as a polymer electrolyte material, a polymer electrolyte molded product and a solid polymer fuel cell respectively using the same. The sulfonic acid group-containing polymer of the present invention is a sulfonic acid group-containing polymer comprising a constituent unit containing a sulfonic acid group (A1), and a constituent unit not containing a sulfonic acid group (A2), wherein the polymer contains a constituent unit having a specified structure as at least one constituent unit containing a sulfonic acid group (A1) at 25 mol % or more based on a sum of the constituent unit containing a sulfonic acid group (A1). Further, the polymer electrolyte material, polymer electrolyte molded product and solid polymer fuel cell of the present invention are constituted using such a sulfonic acid group-containing polymer.

It is an object of the present invention to provide a sulfonic acid group-containing polymer and a sulfonic acid group-containing aromatic compound, which have excellent proton conductivity even under the low humidification condition, are excellent in mechanical strength and chemical stability and, moreover, can attain high output and excellent physical durability when processed into a solid polymer fuel cell, as well as a polymer electrolyte material, a polymer electrolyte molded product and a solid polymer fuel cell respectively using the same. The sulfonic acid group-containing polymer of the present invention is a sulfonic acid group-containing polymer comprising a constituent unit containing a sulfonic acid group (A1), and a constituent unit not containing a sulfonic acid group (A2), wherein the polymer contains a constituent unit having a specified structure as at least one constituent unit containing a sulfonic acid group (A1) at 25 mol % or more based on a sum of the constituent unit containing a sulfonic acid group (A1). Further, the polymer electrolyte material, polymer electrolyte molded product and solid polymer fuel cell of the present invention are constituted using such a sulfonic acid group-containing polymer.

Disclosed are an o-phenyl chalcone compounds and preparation methods and uses thereof. The o-phenyl chalcone compounds are capable of inhibiting the aggregation of microtubules in tumor cells and influencing the mitosis of the cells, and have a high antitumor activity. The compounds also have inhibitory activity against proliferation on various tumor cells, such as a human ovary cancer cell A2780, a human colon cancer cell HCT8, a human breast cancer cell MCF7, a human lung cancer cell A549, a human colon cancer cell SW480, a human nasopharyngeal carcinoma cell CNE2, a human liver cancer cell HepG2 and the like at nanomole concentrations.

Disclosed are an o-phenyl chalcone compounds and preparation methods and uses thereof. The o-phenyl chalcone compounds are capable of inhibiting the aggregation of microtubules in tumor cells and influencing the mitosis of the cells, and have a high antitumor activity. The compounds also have inhibitory activity against proliferation on various tumor cells, such as a human ovary cancer cell A2780, a human colon cancer cell HCT8, a human breast cancer cell MCF7, a human lung cancer cell A549, a human colon cancer cell SW480, a human nasopharyngeal carcinoma cell CNE2, a human liver cancer cell HepG2 and the like at nanomole concentrations.