The present invention belongs to the technical field of medical instruments, and discloses a multifunctional compound light penetration enhanced imaging system and an enhanced imaging method. The structural design of the present invention is reasonable. Through the cooperation of the first working channel tube, the second working channel tube, and the third working channel tube, the size of the channel is switched. When the system shrinks to the minimum, the opening size of the wound is only 1/3 of that when the system is fully opened, which is suitable for a double-channel spinal endoscopic surgery. When the system is expanded to the maximum, it is suitable for transforaminal endoscopic surgery, and is suitable for multiple surgical modes. By adding a special red light component on the basis of the white light to form compound light illumination and increase the system transmittivity, the background penetration is realized.

Systems, methods, and devices for fluorescence imaging with a minimal area image sensor are disclosed. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation, wherein the pixel array comprises active pixels and optical black pixels. The system includes a black clamp circuit providing offset control for data generated by the pixel array and a controller comprising a processor in electrical communication with the image sensor and the emitter. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises electromagnetic radiation having a wavelength from about 795 nm to about 815 nm.

An imaging device includes a light splitting unit which splits first light from a subject into second light and third light, first and second imaging units, and an arithmetic unit. The first light includes the second light having infrared light and at least one of green light and blue light, and the third light having red light or the green light. The first imaging unit includes a first and a second light reception regions. The first light reception region generates at least one of the group consisting of a B signal according to the blue light and a G signal according to the green light. The second light reception region generates an IR signal according to the infrared light. The arithmetic unit generates a visible light image signal from the R signal, the G signal, and the B signal and generates an infrared light image signal from the IR signal.

An endoscope apparatus includes: a light source device radiating at least one or more illumination lights having a predetermined wavelength band to a subject; a CCD picking up an image of a return light from the subject based on radiation of the illumination light from the light source device; an image processing section outputting a first image signal of a first wavelength band having a peak wavelength of spectral characteristic, between a wavelength band including a maximum value and a wavelength band at a minimum value with regard to an absorption characteristic of living tissue, after image pickup by the CCD; and an observation monitor performing image display on the basis of the first image signal.

A medical device comprising an instrument head integral to the medical device having a distal portion, a light source internal to the instrument head coupled to a first channel, a first polarizing filter positioned within the first channel of the instrument head, a second polarizing filter positioned within the second channel for receiving reflected light from the light source, the reflected light received through a sensor axially aligned with the second channel is disclosed herein. The second channel may comprise a distal opening. The second channel may be configured to restrict light from entering the second channel other than by the distal opening. The first polarizing filter may be configured to polarize light from the light source.

A fluorescent type of green light source of a semiconductor in a light source apparatus for an endoscope includes a blue excitation light source device and green emitting phosphor. The blue excitation light source device emits blue excitation light. The green emitting phosphor is excited by the blue excitation light, and emits green fluorescence. A dichroic filter in a dichroic mirror cuts off the blue excitation light from an emission spectrum of mixed light of the blue excitation light and green fluorescence from the fluorescent type of green light source. Thus, illumination light with the emission spectrum of a target can be stably supplied without influence of the blue excitation light to a light amount of blue light from a blue light source of a semiconductor.

An endoscope observation system includes a light source section generating different types of light in at least partly different wavelength bands for observation of a polarized light-based observation image and for observation of a non polarized light-based observation image, respectively; an irradiation side polarization separation element subjecting the illumination light from the light source section to polarization separation; a light reception side polarization separation element performing polarization separation, in a particular wavelength band of the light from the observation target, by transmitting polarized light with a predetermined polarization component while reflecting polarized light with a polarization component other than the predetermined polarization component, and in a wavelength bend other than the particular wavelength band, exhibiting same transmission and reflection characteristics for both polarized light and non polarized light; and an image pickup element receiving the transmitted or reflected light.

The present invention relates to an illumination filter system (2) for medical imaging, in particular multispectral fluorescence imaging, as performed e.g. in a microscope (1) or endoscope, such as a surgical microscope, in particular a surgical multispectral fluorescence microscope, comprising a first optical filter (35). The present invention also relates to an observation system (3) for medical imaging, in particular multispectral fluorescence imaging, as performed e.g. in a microscope (1) or endoscope, in particular a multispectral fluorescence microscope, comprising a beam splitter (21) adapted to split a light image (13) into a first light portion (16, 17) along a first light path (18) and a second light portion (20) along a second light path (19). To improve known illumination filter systems and observation systems, so these systems work with one light source only, are capable of capturing simultaneously at least one fluorescence signal and a signal of visible reflected light and allow a homogeneous illumination for obtaining different images from the object illuminated, the first optical filter (36) is adapted to quench light of at least one fluorescence excitation band within the visible spectrum in the illumination filter system (2) of the present invention, and the first light portion (16, 17) comprises at least one fluorescence emission band (Em.1, Em.2) in the visible spectrum and the second light portion (20) portion comprises a visible reflected light (VISR) in the observation system (3) of the present invention.

The invention relates to an illumination filter (36, 44) for an illumination filter system (2) for medical imaging, in particular multispectral fluorescence imaging, as performed e.g. in a microscope (1) or endoscope, in particular a multispectral fluorescence microscope. The present invention provides an illumination filter for medical imaging, in particular a multispectral fluorescence imaging, that is capable of capturing simultaneously more than one fluorescence signal, and allow a homogeneous illumination for obtaining different images from the object illuminated by comprising a spatial filter pattern (43) masking a defined filtering fraction of a first illumination path (47) on the filter and masking a defined filtering fraction of a second illumination path (48, 49, 50) on the filter, wherein the filtering fraction of the first and the second illumination paths (47, 48, 49, 50) are different. The invention further relates to an illumination filter system (2) for medical imaging, in particular multispectral fluorescence imaging, as performed e.g. in a microscope (1) or endoscope, in particular a multispectral fluorescence microscope, comprising such illumination filter (36, 44).

An image processing device includes a processor including hardware, the processor being configured to implement an image acquisition process that acquires captured images from an imaging section that performs a frame sequential imaging process in which one cycle includes first to N-th frames, and a synthesis process, wherein the processor implements the image acquisition process that acquires a plurality of captured images that have been captured in an i-th frame and differ from each other as to an in-focus object plane position, and the processor implements the synthesis process that calculates a second synthesis map based on a first synthesis map calculated with respect to the i-th frame, and the first synthesis map calculated with respect to a k-th frame, and synthesizes the plurality of images that have been captured in the i-th frame based on the second synthesis map.