Patent classifications
C07C311/03
Novel compounds and their uses as thyroid hormone receptor agonists
A compound of formula (I) or (Ia), or a tautomer or a pharmaceutically acceptable salt thereof is provided. Compounds of formula (II) to (V), or a tautomer or a pharmaceutically acceptable salt thereof are also provided. These compounds and the pharmaceutical compositions containing them are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto. (I), (Ia)
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Novel compounds and their uses as thyroid hormone receptor agonists
A compound of formula (I) or (Ia), or a tautomer or a pharmaceutically acceptable salt thereof is provided. Compounds of formula (II) to (V), or a tautomer or a pharmaceutically acceptable salt thereof are also provided. These compounds and the pharmaceutical compositions containing them are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto. (I), (Ia)
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Synthetic process
- William P. Gallagher ,
- John Ryan Coombs ,
- Carlos A. Guerrero ,
- David Marcoux ,
- Qing Shi ,
- Candice Lee Joe ,
- Sanjeewa Rupasinghe ,
- Jason J. Zhu ,
- Srinivas Kalidindi ,
- Sathasivam Shunmugaraj ,
- Moorthy Kandasamy ,
- Siva Sankar Bondigela ,
- Rajappa Vaidyanathan ,
- Shankar Tulsidas Tendulkar ,
- Sankar Kuppusamy ,
- Francisco González-Bobes
The invention generally relates to a process for preparing compounds, including Compound of Formula (I), useful as key intermediates in the preparation of compounds having RORγt antagonist properties. ##STR00001##
Resist composition and pattern forming process
A resist composition comprising a quencher containing a sulfonium salt having the formula (A). ##STR00001##
Resist composition and pattern forming process
A resist composition comprising a quencher containing a sulfonium salt having the formula (A). ##STR00001##
NOVEL COMPOUND HAVING CANCER METASTASIS INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION FOR INHIBITING CANCER METASTASIS AND INVASION OR TREATING COLORECTAL CANCER, COMPRISING COMPOUND
The present invention provides a novel compound that increases KAI1 promoter activity, a pharmaceutically acceptable salt thereof, and a composition for inhibiting cancer metastasis and invasion or treating colorectal cancer containing the same.
Compositions for the treatment of pulmonary fibrosis
The present invention relates to compounds and their use in the prophylactic and/or therapeutic treatment of pulmonary fibrosis and/or related conditions.
Compositions for the treatment of pulmonary fibrosis
The present invention relates to compounds and their use in the prophylactic and/or therapeutic treatment of pulmonary fibrosis and/or related conditions.
Antiviral compounds
The present invention relates to novel compounds of general formula (I) wherein the groups X, and R.sup.1 to R.sup.4 have the meanings given in the description and claims, process for preparing these compounds and their use as for treating, preventing or ameliorating viral infections and their use for treating, preventing or ameliorating diseases which are associated with PLA2G16. ##STR00001##
Antiviral compounds
The present invention relates to novel compounds of general formula (I) wherein the groups X, and R.sup.1 to R.sup.4 have the meanings given in the description and claims, process for preparing these compounds and their use as for treating, preventing or ameliorating viral infections and their use for treating, preventing or ameliorating diseases which are associated with PLA2G16. ##STR00001##