Patent classifications
C07C311/07
Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: ##STR00001##
wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
INHIBITORS OF THE WNT/BETA-CATENIN PATHWAY
The present disclosure relates to compounds that are capable of modulating the WNT/Beta-Catenin pathway. The disclosure further relates to methods of treating colorectal cancer and other WNT/Beta-Catenin mediated cancers.
INHIBITORS OF THE WNT/BETA-CATENIN PATHWAY
The present disclosure relates to compounds that are capable of modulating the WNT/Beta-Catenin pathway. The disclosure further relates to methods of treating colorectal cancer and other WNT/Beta-Catenin mediated cancers.
HETEROCYCLIC SULFONAMIDES, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF
The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I:
##STR00001##
as defined in the specification. The invention is also directed to compositions containing and uses of the compounds of formula I.
HETEROCYCLIC SULFONAMIDES, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF
The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I:
##STR00001##
as defined in the specification. The invention is also directed to compositions containing and uses of the compounds of formula I.
COMPOUNDS USEFUL AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN DIOXYGENASE
Compounds of formula (VII), which are useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase, are provided. Also provided are pharmaceutical compositions, kits comprising said compounds, and methods and uses pertaining to said compounds.
Process for the preparation of indanones
A process of forming compounds of formula I ##STR00001##
comprising the steps of addition of an amino compound H.sub.2NR to a compound of formula (II) ##STR00002##
followed by cyclization, isomerization and hydrolysis.
Process for the preparation of indanones
A process of forming compounds of formula I ##STR00001##
comprising the steps of addition of an amino compound H.sub.2NR to a compound of formula (II) ##STR00002##
followed by cyclization, isomerization and hydrolysis.
Process for hydrogenating ketones in the presence of Ru(II) catalysts
The present invention relates to a process for hydrogenating a substrate including a carbon-heteroatom double bond, the process including the step of reacting the substrate with hydrogen gas in the presence of a hydrogenation catalyst, wherein the hydrogenation catalyst is a complex of formula (I): ##STR00001##
R.sub.1-10, A and Hal are as defined in the specification. The present invention also provides processes for the preparation of the complex of formula (I) and intermediates thereof.
Process for hydrogenating ketones in the presence of Ru(II) catalysts
The present invention relates to a process for hydrogenating a substrate including a carbon-heteroatom double bond, the process including the step of reacting the substrate with hydrogen gas in the presence of a hydrogenation catalyst, wherein the hydrogenation catalyst is a complex of formula (I): ##STR00001##
R.sub.1-10, A and Hal are as defined in the specification. The present invention also provides processes for the preparation of the complex of formula (I) and intermediates thereof.