C07C323/25

Cleavable Lipids

Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent iransfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.

Synthesis of fluoro hemiacetals via transition metal-catalyzed fluoro ester and carboxamide hydrogenation

This application is directed to use of transition metal-ligand complexes to hydrogenate fluorinated esters and carboxamides into fluorinated hemiacetals. Methods for synthesis of certain ligands are also provided.

Synthesis of fluoro hemiacetals via transition metal-catalyzed fluoro ester and carboxamide hydrogenation

This application is directed to use of transition metal-ligand complexes to hydrogenate fluorinated esters and carboxamides into fluorinated hemiacetals. Methods for synthesis of certain ligands are also provided.

CATIONIC LIPID EXHIBITING IMPROVED INTRACELLULAR DYNAMICS

The invention provides a cationic lipid, a lipid membrane structure containing same, and use thereof. The cationic lipid is represented by the formula (1)

##STR00001##

wherein R.sup.1a, R.sup.1b, R.sup.2a, R.sup.2b, R.sup.3a, R.sup.3b, X.sup.a, X.sup.b, Y.sup.b, Z.sup.a, and Z.sup.b are as defined in the specification.

Cysteamine prodrugs

Described herein are prodrugs of cysteamine and pharmaceutically acceptable salts, solvates, and esters thereof. Also described herein are pharmaceutical compositions comprising prodrugs of cysteamine, or pharmaceutically acceptable salts, solvates, and esters thereof, and methods of treatment comprising administering prodrugs of cysteamine, or pharmaceutically acceptable salts, solvates, and esters thereof.

CARBON QUANTUM DOT, A COMPOSITION THEREOF AND A METHOD FOR TREATING INFECTION BY USING SAME

Provided is a carbon quantum dot having a graphite core and a surface including components, such as compounds derived from formula (I) and halogens, and having a positive charge for antibacterial purposes. Also provided are methods for preparing a carbon quantum dot and a composition containing the same.

CARBON QUANTUM DOT, A COMPOSITION THEREOF AND A METHOD FOR TREATING INFECTION BY USING SAME

Provided is a carbon quantum dot having a graphite core and a surface including components, such as compounds derived from formula (I) and halogens, and having a positive charge for antibacterial purposes. Also provided are methods for preparing a carbon quantum dot and a composition containing the same.

Thiol-formyl hemiacetal corrosion inhibitors

The present invention generally relates to compositions and methods for inhibiting corrosion at a surface in the production, transportation, storage, and separation of crude oil and natural gas.

Thiol-formyl hemiacetal corrosion inhibitors

The present invention generally relates to compositions and methods for inhibiting corrosion at a surface in the production, transportation, storage, and separation of crude oil and natural gas.

SUBSTITUTED AMINO-THIOL AND AMINO-DISULFIDE COMPOUNDS, AND USES THEREOF
20220135524 · 2022-05-05 ·

The disclosure provides for new substituted cysteamine and cystamine compounds, pharmaceutical compositions made thereof, and methods thereof including the treatment of any disease or disorder in a subject that can benefit from one or more of the bioprotective effects of the compounds, including but not limited to, binding of cystine, reducing oxidative stress, increasing adiponectin levels and/or increasing brain-derived neurotrophic factors. Examples of such disease and disorders, include but are not limited to, cystinosis, and fatty liver diseases.