A compound of formula I and a use thereof as an MALT1 inhibitor, and a pharmaceutical composition containing the compound. The compound can be used to treat diseases or disorders such as cancer.

##STR00001##

Personal care compositions, such as oral medication compositions containing a flavor system comprising one or more coolants. The pleasant cool sensation provided by a coolant is enhanced in terms of quicker onset, greater intensity, impact or longer duration, which improves appeal and acceptability of the compositions to consumers.

Personal care compositions, such as oral medication compositions containing a flavor system comprising one or more coolants. The pleasant cool sensation provided by a coolant is enhanced in terms of quicker onset, greater intensity, impact or longer duration, which improves appeal and acceptability of the compositions to consumers.

The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Personal care compositions, such as oral medication compositions containing a flavor system comprising one or more coolants. The pleasant cool sensation provided by a coolant is enhanced in terms of quicker onset, greater intensity, impact or longer duration, which improves appeal and acceptability of the compositions to consumers.

Personal care compositions, such as oral medication compositions containing a flavor system comprising one or more coolants. The pleasant cool sensation provided by a coolant is enhanced in terms of quicker onset, greater intensity, impact or longer duration, which improves appeal and acceptability of the compositions to consumers.

A compound, or pharmaceutically acceptable salt thereof, having a formula I of:

##STR00001## wherein R.sup.1 is H or optionally-substituted alkyl; R.sup.2 is optionally-substituted alkyl; R.sup.3 and R.sup.4 are each independently H or optionally-substituted alkyl; R.sup.5 is H, optionally-substituted alkyl, acyl, or alkoxycarbonyl; R.sup.6 and R.sup.7 are each independently H, deuterium, optionally-substituted alkyl, or R.sup.6 and R.sup.7 together form a carbocyclic; R.sup.8 is optionally-substituted thiazolyl, optionally-substituted thiophenyl, or substituted phenyl, provided that if R.sup.8 is 4-halophenyl, then R.sup.2 is substituted alkyl or branched alkyl or at least one of R.sup.6 or R.sup.7 is not H; and R.sup.30, R.sup.31 and R.sup.32 are each independently H, deuterium, halogen, substituted sulfanyl, or optionally-substituted alkoxy.

A compound, or pharmaceutically acceptable salt thereof, having a formula I of:

##STR00001## wherein R.sup.1 is H or optionally-substituted alkyl; R.sup.2 is optionally-substituted alkyl; R.sup.3 and R.sup.4 are each independently H or optionally-substituted alkyl; R.sup.5 is H, optionally-substituted alkyl, acyl, or alkoxycarbonyl; R.sup.6 and R.sup.7 are each independently H, deuterium, optionally-substituted alkyl, or R.sup.6 and R.sup.7 together form a carbocyclic; R.sup.8 is optionally-substituted thiazolyl, optionally-substituted thiophenyl, or substituted phenyl, provided that if R.sup.8 is 4-halophenyl, then R.sup.2 is substituted alkyl or branched alkyl or at least one of R.sup.6 or R.sup.7 is not H; and R.sup.30, R.sup.31 and R.sup.32 are each independently H, deuterium, halogen, substituted sulfanyl, or optionally-substituted alkoxy.

A method of measuring nitrate concentration in an aqueous sample includes mixing the aqueous sample with a water-soluble thioether chosen to reduce nitrate in the aqueous sample to nitrite in the presence of a water soluble catalyst, and a water soluble reagent system adapted to interact with nitrite to generate a color; measuring color generation, and correlating the color generation to nitrate concentration.